Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

Who May Qualify: - Written willing to sign a consent form (and assent when applicable) obtained from participant or participant's legally authorized representative - For Adults: Must be able to consent on one own's behalf (i.e., cannot lack cognitive capacity to consent due to the required patient-reported outcomes) - Be willing and able to adhere to the study protocol requirements - Age ≥ 12 years at time of enrollment - CF diagnosis based on two CF causing mutations and/or positive sweat test according to CFF diagnostic criteria - CFRD diagnosis ≥ 5 years at time of enrollment Who Should NOT Join This Trial: - History of any illness or condition that, in the opinion of the investigator might confound the results of the study or pose an additional risk to the subject - History of transplant - Pregnancy reported by participant at time of consent or at any point during active study participation Pulse Wave Velocity Who Should NOT Join This Trial: - Erratic, accelerated or mechanically controlled irregular heart rhythms including arrhythmias - Carotid or aortic valve stenosis - Peripheral artery disease or leg artery disease - Generalized constriction or localized spasm of muscular conduit arteries such as seen immediately after hypothermic cardiopulmonary bypass surgery or accompanying Raynaud's phenomena or intense cold. - Possible exclusions based on investigator medical provider assessment (additional precautions may be followed to allow inclusion): - Pressure reading should not be conducted on a limb where there is intravenous access, arterio-venous shunt, or where circulation is compromised. - Pressure reading should not be conducted on the side of the body that a mastectomy was done. Always talk to your doctor about whether this trial is right for you.