RECRUITINGINTERVENTIONAL

Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors

Virtually Delivered Home-Based Exercise Intervention on Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors: A Pilot Randomized Controlled Trial

About This Trial

This clinical trial evaluates the impact of a research intervention of virtually supervised exercise program (RISE) on cancer-related cognitive impairment (CRCI), physical activity in adolescent and young adult (AYA) brain tumor survivors. This clinical trial also evaluates the impact of RISE on the collection of microorganisms that exist in the intestines (gut microbiome). Up to 45% of AYA brain tumor survivors experience CRCI, including issues with attention and memory. CRCI can have a negative impact on education, independent living and can worsen long-term quality of life. Moderate-intensity levels of exercise, particularly aerobic and resistance training, have been shown to improve cognitive function. Additionally, exercise can change the composition and function of the gut microbiome, which may lead to improved cognitive function. Unfortunately, only about 50% of AYAs with cancer receive exercise information or meet the physical activity recommendations. Tailoring a virtually delivered exercise intervention to meet the unique needs of AYAs may improve access to exercise. Participating in the virtual home-based exercise intervention, RISE, may improve physical activity and cognitive impairment in AYA brain tumor survivors and may also help researchers understand the relationship of exercise on the gut microbiome and cognitive function.

Who May Be Eligible (Plain English)

Who May Qualify: - Age 15-39 years - With primary brain tumor with cranial radiotherapy - 6 months to 4 years post cranial radiotherapy - Functional Assessment of Cancer Therapy (FACT)-Cognitive Function score \< 60 based on self-report (used among AYAs with non-neural cancer) - Able to provide willing to sign a consent form/assent - Able to walk and receive clearance from a provider to participate based on the Physical Activity Readiness Questionnaire - Currently engaging in \< 150 minutes of physical activity per week - Willing to use smartphone-based applications (app) Who Should NOT Join This Trial: - Secondary malignancies, germline genetic syndrome, or recurrent disease requiring re-irradiation of the brain - Moderate to severe traumatic brain injury with brain damage beyond that expected from brain tumor and treatment - Developmental disorders (e.g., autism) or major psychotic illness (e.g., schizophrenia, depression) to avoid confounding impact related to these disorders Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Age 15-39 years * With primary brain tumor with cranial radiotherapy * 6 months to 4 years post cranial radiotherapy * Functional Assessment of Cancer Therapy (FACT)-Cognitive Function score \< 60 based on self-report (used among AYAs with non-neural cancer) * Able to provide informed consent/assent * Able to walk and receive clearance from a provider to participate based on the Physical Activity Readiness Questionnaire * Currently engaging in \< 150 minutes of physical activity per week * Willing to use smartphone-based applications (app) Exclusion Criteria: * Secondary malignancies, germline genetic syndrome, or recurrent disease requiring re-irradiation of the brain * Moderate to severe traumatic brain injury with brain damage beyond that expected from brain tumor and treatment * Developmental disorders (e.g., autism) or major psychotic illness (e.g., schizophrenia, depression) to avoid confounding impact related to these disorders

Treatments Being Tested

OTHER

Aerobic Exercise

Participate in personalized, progressive aerobic training

BEHAVIORAL

Behavioral Intervention

Receive active lifestyle behavior coaching

PROCEDURE

Follow-Up

Receive calls from the trainer

OTHER

Internet-Based Intervention

Receive access to Physitrack

OTHER

Medical Device Usage and Evaluation

Wear a Fitbit monitor

OTHER

Questionnaire Administration

Ancillary studies

OTHER

Resistance Training

Participating in strength training exercises

Locations (2)

Emory University Hospital

Atlanta, Georgia, United States

MD Anderson Cancer Center

Houston, Texas, United States