A Study of Females With CF Throughout Pregnancy and Post-partum, and Follow up of Their Offspring

Who May Qualify: 'Mama' sub-study: - Written willing to sign a consent form obtained from participant. - Under the care of Royal Brompton Hospital CF Reproductive and Maternal Health Service - Age 16 years or above at time of recruitment - Confirmed diagnosis of CF - Planning a pregnancy or pregnant at time of recruitment. - Ability to adhere to the required visits and investigations. 'Mini' sub-study: - Written willing to sign a consent form obtained from participant's legal guardian. - Infants who have one biological parent with a confirmed diagnosis of CF under care of Royal Brompton Hospital Adult CF Service - Less than 12 months of age at first visit. - Ability to adhere to the required visits and investigations. 'Midi' sub-study: - Written willing to sign a consent form obtained from participant's legal guardian. - Children who have one biological parent with a confirmed diagnosis of CF who is under the care of Royal Brompton Hospital Adult CF Service. - Age three to six years at time of visit - Ability to adhere to the required visits and investigations. Who Should NOT Join This Trial: 'Mama' sub-study: - Any significant health condition which would cause inability to comply with protocol based on investigator discretion. - History of lung transplantation 'Mini' sub-study: - Legal guardians' inability to provide consent to participate in the study. - Mother of infant has significant comorbidities unrelated to CF which could affect infant outcomes based on investigator discretion. 'Midi' sub-study: - Legal guardians' inability to provide consent to participate in the study. - A significant health condition which is known to affect lung function or imaging based on investigator discretion Always talk to your doctor about whether this trial is right for you.