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RECRUITINGINTERVENTIONAL

Comparison of the Efficacy of Celiac Plexus Blockade, ESP and Lidocaine Infusion Under OFA

Comparison of the Efficacy of Celiac Plexus Blockade, Erector Spinae Compartment Blockade (ESP), and Intravenous Lidocaine Infusion Under Opioid-free Anesthesia in Patients Undergoing Bariatric Surgery

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Modern anesthesiology, in search of alternatives to opioid-based pain management, is turning to low-opioid and non-opioid protocols. Replacing opioids with non-opioid analgesics, co-analgesics, and regional and local anesthesia techniques allows avoiding the adverse effects of opioids while maintaining satisfactory analgesia. This is of particular importance in bariatric surgery, where reducing the incidence of respiratory depression, sedation, opioid hyperalgesia, and postoperative nausea and vomiting is a priority. Standard non-opioid anesthesia (OFA) includes ketamine, lidocaine, and dexmedetomidine infusions, while regional techniques additionally reduce the need for analgesics. Despite the widespread use of these methods, there is no clear data on the superiority of any of them in bariatric procedures.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients over 18 years who underwent laparoscopic bariatric surgery - Must be able to sign agreement for study Who Should NOT Join This Trial: - Patients with a history of allergic reactions to drugs - Patients with a history of drug addiction - Patients with chronic pain who require analgesics - History of hospitalization for psychiatric disorders - Preoperative pulse oximetry (SpO2) \< 95 % - bradycardia (HR\<50bpm) - hypotension - atrioventricular block - intraventricular or sinus block - Blood clotting disorders - Pregnant/lactating women - Cognitive impairment - Unable to read consent Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients over 18 years who underwent laparoscopic bariatric surgery * Must be able to sign agreement for study Exclusion Criteria: * Patients with a history of allergic reactions to drugs * Patients with a history of drug addiction * Patients with chronic pain who require analgesics * History of hospitalization for psychiatric disorders * Preoperative pulse oximetry (SpO2) \< 95 % * bradycardia (HR\<50bpm) * hypotension * atrioventricular block * intraventricular or sinus block * Blood clotting disorders * Pregnant/lactating women * Cognitive impairment * Unable to read consent

Treatments Being Tested

DRUG

Celiac Plexus Block

During general anesthesia, a celiac plexus block will be performed intraoperatively (20 ml of 0.5% ropivacaine). The patient will not feel discomfort due to general anesthesia.

DRUG

ESP block

Before the procedure, a block of the erector spinae (ESP) compartment will be performed with approximately 20 ml of 0.25% ropivacaine at the Th4 level. The patient will be informed about the possibility of short-term discomfort if the block is performed before full induction of anesthesia.

DRUG

Lidacaine

Instead of a regional block, an intravenous infusion of lidocaine will be used.

Locations (1)

Department of Intensive Interdisciplinary Care, Collegium Medicum, Jagiellonian University
Krakow, Lesser Poland Voivodeship, Poland