the Role of cArdiac Inflammation, endoThelial Dysfunction, and FIbrosis in fabrY Disease

Patients with Fabry disease (1) Who May Qualify: - Male and female individuals with a genetically-verified diagnosis of Fabry disease - ≥ 18 years of age - Able to give willing to sign a consent form Who Should NOT Join This Trial: - Any contraindication against a pharmacologically induced rest-stress PET/CT protocol according to local safety procedures such as acute coronary syndrome, severe bronchospasm, severe chronic obstructive pulmonary disease, cardiac arrhythmia. - Any contraindication for MRI according to standard checklist used in clinical routine, including claustrophobia or metallic foreign bodies, metallic implants, internal electrical devices, or permanent makeup/tattoos that cannot be declared MR compatible. - Pregnancy Age and sex-matched healthy controls (2) Who May Qualify: - ≥ 18 years of age - Able to give willing to sign a consent form Who Should NOT Join This Trial: - A genetically-verified diagnosis of Fabry disease. - Family member to a patient with a genetically-verified diagnosis of Fabry disease - Cancer expected to influence life expectancy. - Known heart failure, previous apoplexy or previously established kidney disease. - Initiation or change of antihypertensive therapy within 3 months of enrollment. - Known LVH as evaluated on echocardiography - Any contraindication for a pharmacologically induced stress PET/CT protocol according to local safety procedures such as acute coronary syndrome, severe bronchospasm, severe chronic obstructive pulmonary disease, cardiac arrhythmia. - Any contraindication for MRI according to standard checklist used in clinical routine, including claustrophobia or metallic foreign bodies, metallic implants, internal electrical devices, or permanent makeup/tattoos that cannot be declared MR compatible. - Pregnancy Always talk to your doctor about whether this trial is right for you.