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RECRUITINGOBSERVATIONAL

Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP)

Efficacy of Robot-assisted Walking Treatment on Gait Biomechanics, Functional Outcomes, and Quality of Life in Subjects With Hereditary Spastic Paraplegia (HSP)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Patients will undergo a combined rehabilitation treatment consisting of 15 sessions on Lokomat and 15 sessions of physical therapy over three weeks for a total of 30 sessions. Two sessions/day for 5 days a week. The same subjects will conduct clinical-functional assessments before, at the end of treatment, and after a 3-month follow-up: 3D Gait Analysis with defined protocol (BTSBioenginner); Spastic Paraplegia Rating Scale (SPRS); Six-Minute Walk Test (6MWT), Ten Meters Walk Test (10MWT), Gross Motor Function Measure-88 (GMFM-88) and Berg Balance Scale (BBS); Quality of life questionnaires: Medical Outcome Survey Short Form (SF-36) and ad hoc questionnaire for subjective assessment of symptoms during walking (HSP-SNAP). This study is part of normal clinical practice and does not involve any changes to the current rehabilitation course for patients.

Who May Be Eligible (Plain English)

Who May Qualify: - genetic or clinical diagnosis of HSP. - age greater than 4 years and less than 70 - femur length \> 23 cm - ability to walk independently indoors, with or without walking aids. Who Should NOT Join This Trial: - botulinum toxin injection or lower limb surgery in the previous 6 months - severe lower limb muscle retractions - severe osteoporosis - unhealed skin lesions in lower limbs - cardiovascular instability - acute or progressive neurological disorders - behavioral problemS Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * genetic or clinical diagnosis of HSP. * age greater than 4 years and less than 70 * femur length \> 23 cm * ability to walk independently indoors, with or without walking aids. Exclusion Criteria: * botulinum toxin injection or lower limb surgery in the previous 6 months * severe lower limb muscle retractions * severe osteoporosis * unhealed skin lesions in lower limbs * cardiovascular instability * acute or progressive neurological disorders * behavioral problemS

Treatments Being Tested

DEVICE

Robot-Assisted Gait Training

15 sessions of robot-assisted gait training(LOKOMAT)+ 15 session of usual treatment for a total of 30 sessions in three weeks. 45 minutes for each session.

Locations (1)

Irccs Eugenio Medea
Bosisio Parini, Italy/lecco, Italy