Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia

Who May Qualify: Aged ≥18 with penicillin susceptible S. aureus bacteraemia (PSSA), and able to provide written willing to sign a consent form. Who Should NOT Join This Trial: - allergy to penicillin, - inability to give willing to sign a consent form, - concomitant growth of other clinically significant bacteria in blood cultures - neutropenia -≥ 96h with prior antibiotics - When the per oral follow up medication can not be flukloxacillin or penicillinV/Amoxicillin (ie prosthetic joint infection) - Patients in terminal palliation, where death is expected within 7 days. - Where the treating physician believes cloxacillin is not a first-line treatment. Always talk to your doctor about whether this trial is right for you.