Assessing the Utility of Prophylactic Antibiotics at Time of Urethral Bulking Using Bulkamid (Bulkamid Study)

Inclusion Criteria - Patients evaluated by a pelvic floor specialist (either urogynecologist or urologist) at The Ohio State University with plans to undergo urethral bulking with Bulkamid for stress urinary incontinence or mixed urinary incontinence (stress predominant). - Negative testing for UTI in pre-operative work-up (including either negative urine culture or urine dip negative for infection). - Office evaluation with evidence of SUI either with urodynamic studies (UDS) or positive cough stress test (CST). - Post-void residual volume of 150 mL or less (measured by either catheterization or bladder scan) Exclusion Criteria - Contraindications to both oral antibiotics including antibiotic allergies or significant renal disease - Patient undergoing additional pelvic organ prolapse procedures or other urologic procedures concomitantly - Recurrent UTIs, defined as 3 or more UTIs within the past 12 months or 2 UTIs within the past 6 months - Patients currently taking daily antibiotic prophylaxis for any reason - Non-English speaking patients - Pregnant patients - Pelvic organ prolapse stage greater than 2 - Patients with immunosuppression due to underlying medical conditions - Recent antibiotic treatment within one week of the procedure Always talk to your doctor about whether this trial is right for you.