RECRUITINGEarly Phase 1INTERVENTIONAL

Working Memory Training for People Aging with HIV

A Feasibility Study of Working Memory Training for People Aging with HIV

About This Trial

The present study investigates the feasibility of working memory training in people aging with HIV (PAWHIV). In a cross-over design this stage 1 feasibility trial, will evaluate acceptability, and estimate possible effect sizes related to working memory training by examining potential differential effects in PAWHIV and those aging without HIV. This project highlights the importance of tailored cognitive assessments and interventions, engaging with underrepresented communities to enhance inclusivity in cognitive health research.

Who May Be Eligible (Plain English)

Who May Qualify: - 50-85 years of age - Able to understand and speak English and follow study procedures - Does not have a psychological or neurological condition that would prevent being able to give consent to participate - Not currently involved in any other cognitive or memory training studies Who Should NOT Join This Trial: - Formal diagnosis of dementia or other neurological disease, including Mild cognitive impairment. - A final total score below 17 on Montreal Cognitive Assessment - Blind (telephone) version. - Score of 10 or more on the Generalized Anxiety Questionnaire (GAD7; Spitzer et al., 2006, Archives of Internal Medicine), indicating presence of moderate or severe anxiety - Score of 9 or more on Geriatric depression scale (GDS15; Yesavage et al., 1982) indicating presence of moderate or severe depression - Abnormal visual acuity prohibitive of tablet-based training. - Physical handicap (motor or perceptual) that would impede training procedures. - Medical illness requiring treatment and/or significant absences during the study timeline. - Current evidence or 2-yr history of seizures, focal brain lesion, or head injury with loss of consciousness. - Current alcohol consumption exceeds 14 drinks per week. - Self-reported illicit drug use. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * 50-85 years of age * Able to understand and speak English and follow study procedures * Does not have a psychological or neurological condition that would prevent being able to give consent to participate * Not currently involved in any other cognitive or memory training studies Exclusion Criteria: * Formal diagnosis of dementia or other neurological disease, including Mild cognitive impairment. * A final total score below 17 on Montreal Cognitive Assessment - Blind (telephone) version. * Score of 10 or more on the Generalized Anxiety Questionnaire (GAD7; Spitzer et al., 2006, Archives of Internal Medicine), indicating presence of moderate or severe anxiety * Score of 9 or more on Geriatric depression scale (GDS15; Yesavage et al., 1982) indicating presence of moderate or severe depression * Abnormal visual acuity prohibitive of tablet-based training. * Physical handicap (motor or perceptual) that would impede training procedures. * Medical illness requiring treatment and/or significant absences during the study timeline. * Current evidence or 2-yr history of seizures, focal brain lesion, or head injury with loss of consciousness. * Current alcohol consumption exceeds 14 drinks per week. * Self-reported illicit drug use.

Treatments Being Tested

BEHAVIORAL

Span

The training program is a personal device-based adaptive version of a visual working memory span task, either devoid of game elements or embedded in a gamified platform game

Locations (1)

Northeastern University

Boston, Massachusetts, United States