Wide-Antral Pulmonary Vein Isolation in Atrial Fibrillation Ablation with a Single-shot Technique (WIDER-PVI)

Who May Qualify: - Age over 18 years old. - Previous diagnosis of paroxysmal or persistent atrial fibrillation less than 2 years after diagnosis. - Clinical indication to undergo a pulmonary vein isolation procedure using balloon cryoablation. Who Should NOT Join This Trial: - Severe left atrial dilatation (indexed volume \>48 ml/m2 or area \>40 cm2 or indexed diameter \>3.0 cm/m2). - Previous endocardial or surgical ablation of atrial fibrillation. - Severe frailty (Clinical Frailty Scale score 7 or higher) or life expectancy less than 1 year. - Inability to understand or give willing to sign a consent form. - Performance of other left atrial ablations in addition to pulmonary veins. - Need to use another catheter in addition to the cryoablation catheter to complete pulmonary vein isolation. - Contraindication to anticoagulation or intolerance to heparin. - Presence of intra-atrial thrombus. - Reversible cause of atrial fibrillation. - Severe mitral or aortic valve disease. - Congenital heart disease. - Pregnancy or the prospect of pregnancy in the next 12 months. Always talk to your doctor about whether this trial is right for you.