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RECRUITINGINTERVENTIONAL

Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of OCD

A Preliminary Study on the Efficacy and Influencing Factors of Deep Transcranial Magnetic Stimulation in the Treatment of Obsessive-compulsive Disorder

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study aims to explore the efficacy and influencing of accelerated dTMS (deep Transcranial Magnetic Stimulation) treatment in patients with obsessive-compulsive disorder (OCD), and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).

Who May Be Eligible (Plain English)

Who May Qualify: - Aged between 18 and 50, both genders are welcome. - DSM-5 criteria for OCD. - Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study. - More than 9 years of education. - Right-handed. Who Should NOT Join This Trial: - Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder. - Severe obsessive symptoms prevent the completion of necessary assessments. - Has a history of receiving ECT therapy. - Has received rTMS or tDCS treatment within the past two months. - Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others. - Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or a history of brain surgery. - Has implanted medical devices such as intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, etc. - Serious suicide risk. - Pregnancy or nursing of an infant. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Aged between 18 and 50, both genders are welcome. * DSM-5 criteria for OCD. * Y-BOCS total score ≥ 20 despite therapeutic-dose SRI treatment or completion of at least one full course of CBT. The treatment regimen must have been stable for at least 8 weeks prior to enrollment and remain unchanged throughout the study. * More than 9 years of education. * Right-handed. Exclusion Criteria: * Any additional current psychiatric comorbidity, except for obsessive- compulsive personality disorder. * Severe obsessive symptoms prevent the completion of necessary assessments. * Has a history of receiving ECT therapy. * Has received rTMS or tDCS treatment within the past two months. * Has severe physical illnesses or any physical conditions that can induce epilepsy or intracranial hypertension, including cardiovascular and respiratory diseases, among others. * Has a past history of neurological disorders (such as epilepsy, cerebrovascular accidents, etc.) or brain injuries, or a history of brain surgery. * Has implanted medical devices such as intracranial stents, cardiac pacemakers, coronary stents, cochlear implants, etc. * Serious suicide risk. * Pregnancy or nursing of an infant.

Treatments Being Tested

DEVICE

Deep Transcranial Magnetic Stimulation, DTMS active

The treatment plan is to perform 2 treatments per day for 20 minutes each time, for a total of 28 treatments. Each treatment stimulates at a frequency of 20 Hz for 2 seconds, with a sequence interval of 20 seconds. Each treatment consists of 50 sequences, for a total of 2000 pulses.

DEVICE

Deep Transcranial Magnetic Stimulation, DTMS sham

The treatment plan is to perform 2 treatments per day for 20 minutes each time, for a total of 28 treatments. Compared with active treatment, the sham stimulation coil only produced sound and scalp vibration.

Locations (1)

Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China