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RECRUITINGINTERVENTIONAL

Effect of Alternate Day Fasting Over Standard Medical Management Alone to Reverse Non-alcoholic Steatohepatitis.

Effect of Alternate Day Fasting Over Standard Medical Management Alone to Reverse Non-alcoholic Steatohepatitis(NASH), A Randomized Controlled Trial. FAST Trial"

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aims of this study are as follows: To compare the role of alternate-day fasting over standard medical management alone to reverse NASH.

Who May Be Eligible (Plain English)

Who May Qualify: - Age 18-65 years. BMI 25-40kg/m3, and CAP more than 290 - Stable weight in the last 3 months prior to enrolling in the study(\<5kg weight variation) - Imaging showed steatotic liver disease, liver stiffness \<14kPa measured by fibroscan - Histologically proven NASH/MASH, fibrosis up to F3 - Subjects willing to participate in the study Exclusion Criter - Liver stiffness \>14kPa measured by fibroscan or Fibrosis \>F3 - Diabetes with HbA1c\>8.5% - Patients with another co-existing active liver disease e.g. hepatitis B or C, alcoholic liver disease - Patients with cirrhosis, hepatocellular carcinoma(HCC), or other malignancy - Chronic kidney disease, cardiovascular disorders, uncontrolled hypertension - Chronic infections, chronic inflammatory diseases - Patients on weight loss medications e.g semaglutide - Pregnant or lactating women and those planning a pregnancy A patient who is not willing to participate in the study or failed to provide the consent Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age 18-65 years. BMI 25-40kg/m3, and CAP more than 290 * Stable weight in the last 3 months prior to enrolling in the study(\<5kg weight variation) * Imaging showed steatotic liver disease, liver stiffness \<14kPa measured by fibroscan * Histologically proven NASH/MASH, fibrosis up to F3 * Subjects willing to participate in the study Exclusion Criter * Liver stiffness \>14kPa measured by fibroscan or Fibrosis \>F3 * Diabetes with HbA1c\>8.5% * Patients with another co-existing active liver disease e.g. hepatitis B or C, alcoholic liver disease * Patients with cirrhosis, hepatocellular carcinoma(HCC), or other malignancy * Chronic kidney disease, cardiovascular disorders, uncontrolled hypertension * Chronic infections, chronic inflammatory diseases * Patients on weight loss medications e.g semaglutide * Pregnant or lactating women and those planning a pregnancy A patient who is not willing to participate in the study or failed to provide the consent

Treatments Being Tested

BEHAVIORAL

Alternate day fasting

Alternate day fasting

Locations (1)

Institute of Liver and Biliary Sciences
Delhi, India