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RECRUITINGPhase 1INTERVENTIONAL

Inflammatory Challenge and Fear

Inflammatory Challenge and Fear Extinction: A Model to Enhance Understanding of Posttraumatic Stress Disorder

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.

Who May Be Eligible (Plain English)

Who May Qualify: All Subjects: 1. Aged 18-60 years old 2. Trauma Exposed 3. Current PTSD/No history of PTSD Who Should NOT Join This Trial: 1. Contraindications to typhoid vaccine 2. Conditions associated with inflammation 3. Pregnancy or plans to become pregnant in next three months Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: All Subjects: 1. Aged 18-60 years old 2. Trauma Exposed 3. Current PTSD/No history of PTSD Exclusion Criteria: 1. Contraindications to typhoid vaccine 2. Conditions associated with inflammation 3. Pregnancy or plans to become pregnant in next three months

Treatments Being Tested

BIOLOGICAL

Typhoid VI Polysaccharide Vaccine Injectable Solution

Salmonella typhi capsular polysaccharide vaccine (Typhoid Vi Polysaccharide Vaccine): Each dose of 0.5ml Salmonella typhi capsular polysaccharide vaccine (Sanofi Pasteur, SA) is formulated to contain 25μg of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7±0.3), 4.150mg of sodium chloride, 0.065mg of disodium phosphate, 0.023mg of monosodium phosphate and 0.5ml of sterile water for injection. It is indicated for use by humans aged 2 years and older for protection against typhoid fever.

OTHER

Saline Placebo (0.5mL injection)

The placebo injection will consist of 0.5mL of saline.

Locations (1)

San Francisco VA Health Care System
San Francisco, California, United States