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RECRUITINGINTERVENTIONAL

AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

AMD and Validating Rod-Meditated Dark Adaptation With Everyday Task Performance

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.

Who May Be Eligible (Plain English)

Who May Qualify: - Capable and willing to provide consent - Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls - At least 50 years of age Who Should NOT Join This Trial: - Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading - Under 50 years of age - Presence of dense cataracts in the study eye (s) that can affect visual function tests - Presence of glaucoma requiring treatment during the study and/or visual field defects - Previous retinal laser or surgical therapy in the study eye(s) - Previous retinal laser or surgical therapy in the study eye(s) - Any other ocular condition requiring long-term therapy or surgery during the study - The participant has photographically significant corneal or media opacities in either eye that would preclude adequate ophthalmic imaging and functional testing - Diagnosis of nystagmus that will interfere with testing - High myopia -8 Diopters or more severe - The participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations, and outcome assessments. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Capable and willing to provide consent * Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls * At least 50 years of age Exclusion Criteria: * Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading * Under 50 years of age * Presence of dense cataracts in the study eye (s) that can affect visual function tests * Presence of glaucoma requiring treatment during the study and/or visual field defects * Previous retinal laser or surgical therapy in the study eye(s) * Previous retinal laser or surgical therapy in the study eye(s) * Any other ocular condition requiring long-term therapy or surgery during the study * The participant has photographically significant corneal or media opacities in either eye that would preclude adequate ophthalmic imaging and functional testing * Diagnosis of nystagmus that will interfere with testing * High myopia -8 Diopters or more severe * The participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations, and outcome assessments.

Treatments Being Tested

DIAGNOSTIC_TEST

Streetlab VR

Streetlab VR is a virtual reality headset that is warn to simulate walking through a maze at different light levels.

Locations (1)

Duke Eye Center
Durham, North Carolina, United States