RECRUITINGINTERVENTIONAL
AdLip: Human Coach-supported Digital/AI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medication
AdLip: Use of Human Coach-supported Digital/AI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medications: a Multi-centre Randomised Controlled Trial
About This Trial
Investigators hypothesize that the use of a human coach-supported digital/AI personal health assistant (app) will improve adherence to cholesterol-lowering medications (statins with or without ezetimibe) among patients with hyperlipidaemia and suboptimal LDL-C control, when compared to standard care.
Who May Be Eligible (Plain English)
Who May Qualify:
- Between 21 to 84 years old
- Prescribed statins with or without ezetimibe for hyperlipidaemia.
- Medication non-adherence as defined by the \"Extent to Non-adherence\" sub-scale of the DOSE Non-Adherence Measure), with a score \> 1 (range from 0-15)
- Singapore residents (citizens, permanent residents, or long-term pass holders).
- In possession of a smartphone or tablet with Android or iOS operating systems.
- Have internet access on their mobile devices.
Who Should NOT Join This Trial:
- Does not read or understand English. Current use of smartphone medication adherence app(s) that include statins.
- Concurrent use of PCSK9 Inhibitors in addition to statins and/or ezetimibe
- Participation in another study that uses medications that could affect lipid levels
- Severe renal impairment defined as chronic kidney disease stage 4 and above.
- Severe liver disease (Child-Pugh Class C)
- Existing muscular-related complaints or diagnoses which may confound adverse event reporting
- Uncorrected thyroid conditions, especially poorly-controlled hypothyroidism
- Documented psychiatric diagnosis or history of mental illness or deemed as unable to give willing to sign a consent form.
- Currently pregnant, breastfeeding or expecting to get pregnant during the course of the study (1 year).
- Guarded prognosis with expectant mortality within 12 months or less.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Between 21 to 84 years old
* Prescribed statins with or without ezetimibe for hyperlipidaemia.
* Medication non-adherence as defined by the \"Extent to Non-adherence\" sub-scale of the DOSE Non-Adherence Measure), with a score \> 1 (range from 0-15)
* Singapore residents (citizens, permanent residents, or long-term pass holders).
* In possession of a smartphone or tablet with Android or iOS operating systems.
* Have internet access on their mobile devices.
Exclusion Criteria:
* Does not read or understand English. Current use of smartphone medication adherence app(s) that include statins.
* Concurrent use of PCSK9 Inhibitors in addition to statins and/or ezetimibe
* Participation in another study that uses medications that could affect lipid levels
* Severe renal impairment defined as chronic kidney disease stage 4 and above.
* Severe liver disease (Child-Pugh Class C)
* Existing muscular-related complaints or diagnoses which may confound adverse event reporting
* Uncorrected thyroid conditions, especially poorly-controlled hypothyroidism
* Documented psychiatric diagnosis or history of mental illness or deemed as unable to give informed consent.
* Currently pregnant, breastfeeding or expecting to get pregnant during the course of the study (1 year).
* Guarded prognosis with expectant mortality within 12 months or less.
Treatments Being Tested
BEHAVIORAL
Human Coach-supported Digital/AI Personal Health Assistant to Improve Adherence to Lipid-Lowering Medications
Receive personalised feedback and educational content curated by local clinicians and pharmacists through the CADENCE D-PHA app coupled with six sessions of human coaching on top of usual clinical care for lipid management over 6 months
Locations (2)
National Healthcare Group Polyclinics
Singapore, Singapore
National University Polyclinics
Singapore, Singapore