Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia

Who May Qualify: Group A (patients with acute cardiac disease) - Male or female - Age ≥ 40years old - Hospitalized for acute coronary syndrome for less than 7 days. - willing to sign a consent form from the patient - Person insured under a health insurance scheme Group B (patients with chronic cardiovascular disease) - Male or female, - Age ≥ 40 years old - Undergoing coronary artery by-pass surgery - Hospitalized in intensive care unit for \> 12 hours - willing to sign a consent form from the patient - Person insured under a health insurance scheme Group C (patients at risk of CVRD without chronic cardiovascular disease) - Male or female, - Age ≥ 40 years old - Familial high levels of cholesterol or triglycerides - With no personal history of CVRD, with a recent negative cardiac exercise test (last test inferior to 12 months) - Follow-up for lipid abnormalities at high risk of CVRD events - willing to sign a consent form from the patient - Person insured under a health insurance scheme Group D (patients with HAP) - Male or female - Age ≥ 40years old - With one or more risk factors for CVD among: smoking, abnormal lipidic levels, high blood pressure, obesity, diabetes mellitus, chronic kidney disease - Cured from mechanically ventilated HAP during the current hospitalization - willing to sign a consent form from the patient or relatives - Person insured under a health insurance scheme Who Should NOT Join This Trial: - o Groups A, B, C and D - Age \>80 years old - Immunosuppression pre-existing to the index hospitalisation, defined as lymphopenia \< 500 elements/mm3, haematologic cancer, aplasia, chemotherapy/radiotherapy for cancer within 3 months prior to the inclusion, or anti-graft rejection drug. - Pregnant women, breastfeeding women. - Adults under guardianship or trusteeship. - Low probability of survival at day 28. o Groups A, B, C - Community-acquired pneumonia or Hospital-acquired pneumonia within the last year. Always talk to your doctor about whether this trial is right for you.