Kidney Function in People With Cystic Fibrosis in the Era of HEMT

Who May Qualify: 1. Outpatient CF Cohort - Diagnoses of Cystic Fibrosis - Age \> 30 years old - Able to provide willing to sign a consent form 2. Inpatient CF Cohort - Diagnoses of Cystic Fibrosis - Age \> 7 years old - Able to provide willing to sign a consent form and assent (where applicable) - 55 PwCF frequently hospitalized for a pulmonary exacerbation (\>1 hospital admission in the prior 12 months) - 55 PwCF sporadically hospitalized for a pulmonary exacerbation (no hospital admissions in the prior 12 months) - Able to provide urine sample independently 3. Healthy Controls - Healthy, as per participant self-report - Age between 30-50 years - Able to provide willing to sign a consent form Who Should NOT Join This Trial: 1. Outpatient CF Cohort - History of any organ transplant - History of weakened immune system - Previous or current cancer diagnoses - Pregnant or breastfeeding - On chronic dialysis - Non-compliance (demonstrated by \<2 visits during the 12 months before enrollment) 2. Inpatient CF Cohort - The initiation of intravenous antibiotic therapy after hospital admission before obtaining the first blood and urine sample - History of any organ transplant - History of weakened immune system - Previous or current cancer diagnoses - Pregnant or breastfeeding - On chronic dialysis 3. Healthy Controls - History or current kidney disease, organ transplantation, cancer, or any other chronic illness - Current use of antibiotics - Urinary symptoms or UTI (dysuria, frequency, urgency) - Pregnant women - Menstruating on the study visit day - Blood relatives of PwCF Always talk to your doctor about whether this trial is right for you.