RECRUITINGINTERVENTIONAL
Cardiac Radioablation for VT
A Phase I/II Study of Cardiac Radioablation for Refractory Ventricular Tachycardia
About This Trial
The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR) .
Who May Be Eligible (Plain English)
Who May Qualify:
- Participants must be 18 years or older.
- Automatic implanted cardiac defibrillator present.
- VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm.
- Ejection fraction ≥20%.
- At least one previous cardiac ablation for VT.
- VT refractory despite antiarrhythmic medications.
- Likely to live for 12 months in the absence of VT.
- AICD in a position in the chest RT to be given without direct radiation.
- Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT.
- The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice.
Who Should NOT Join This Trial:
- Class IV heart failure
- Abandoned leads.
- Prior radiation therapy to the chest or upper abdomen.
- Interstitial lung disease.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Participants must be 18 years or older.
* Automatic implanted cardiac defibrillator present.
* VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm.
* Ejection fraction ≥20%.
* At least one previous cardiac ablation for VT.
* VT refractory despite antiarrhythmic medications.
* Likely to live for 12 months in the absence of VT.
* AICD in a position in the chest RT to be given without direct radiation.
* Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT.
* The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice.
Exclusion Criteria:
* Class IV heart failure
* Abandoned leads.
* Prior radiation therapy to the chest or upper abdomen.
* Interstitial lung disease.
Treatments Being Tested
RADIATION
Stereotactic Body Radiation Therapy (SBRT)
Stereotactic body radiation therapy, which delivers precise, high-dose radiation non-invasively to generate thermal scarring to myocardial targets causing VT
Locations (1)
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, United States