RECRUITINGINTERVENTIONAL

Precision Medicine in Alzheimer's Disease : Integration of Resilience Metrics and Risk Factors - Validation Cohort BioCogBank-AD

Precision Medicine in Alzheimer's Disease: Integration of Resilience Metrics and Risk Factors - Validation Cohort BioCogBank-AD

About This Trial

BioCogBankAD aims at building a prospective clinical practice cohort of 244 patients with biologically confirmed mild cognitive impairment due to Alzheimer's Disease (AD) or mild AD in order to validate data regarding markers of resilience toward AD pathophysiological process discovered in an upstream project called AD-Resilience.

Who May Be Eligible (Plain English)

Who May Qualify: - Diagnosis of AD according to IWG-2 2014 criteria - Age 50-90 year old - Affiliated or beneficiary of a social security scheme - MMSE ≥ 20 - Abnormal CSF Aβ42 or Aβ40/Aβ42 ratio according to local cut-offs - Abnormal CSF phosphorylated and total Tau according to local cut-offs - Ability to pass neuropsychological assessments - Availability of a brain MRI with T1 volumetric sequence performed within 1 year Who Should NOT Join This Trial: - Other cause of dementia - Participation in an AD therapeutic clinical trial - Protected adults (including individual under guardianship by court order), Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Diagnosis of AD according to IWG-2 2014 criteria * Age 50-90 year old * Affiliated or beneficiary of a social security scheme * MMSE ≥ 20 * Abnormal CSF Aβ42 or Aβ40/Aβ42 ratio according to local cut-offs * Abnormal CSF phosphorylated and total Tau according to local cut-offs * Ability to pass neuropsychological assessments * Availability of a brain MRI with T1 volumetric sequence performed within 1 year Exclusion Criteria: * Other cause of dementia * Participation in an AD therapeutic clinical trial * Protected adults (including individual under guardianship by court order),

Treatments Being Tested

OTHER

Blood sample

Plasma, DNA, RNA and PBMC Sampling

BEHAVIORAL

Neuropsychological battery tests

* Short term memory: Digit span (forward and backward) * Long term memory: Free and Cued selective reminding Test * Language and semantic Memory : Verbal Fluency (Category and Litteral), Image Naming (DO 40) * Praxis * Visuo Spatial abilities: Rey-Osterrieth Complex Figure Test * Attention and executive functions: Trail Making Test (TMT) Part A and B, Frontal Assessment Battery (FAB) * Autonomy in daily life activities : Alzheimer's Disease Cooperative Study - Activities of Daily Living Inventory (ADCS-ADL), Instrumental Activities of Daily Living (IADL) * Mood and anxiety: Hospital Anxiety and Depression Scale (HADS) * Cognitive reserve : Cognitive Reserve Index questionnaire (CRIq)

Locations (1)

Hôpital Cochin

Paris, France