RECRUITINGOBSERVATIONAL
National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry
About This Trial
The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data. The main questions it aims to answer are: Which genes are most commonly affected? What is the frequency of these genetic alterations in our population? Participants will be interviewed in routine medical care visits and their DNA will be sequenced.
Who May Be Eligible (Plain English)
Who May Qualify:
- Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines
- Agree to receive genetic counseling
- Sign willing to sign a consent form form
- Provide the information required in the case report form
Who Should NOT Join This Trial:
- Signature absent from willing to sign a consent form form
- Inadequate buccal swab (sample may be collected twice)
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines
* Agree to receive genetic counseling
* Sign informed consent form
* Provide the information required in the case report form
Exclusion Criteria:
* Signature absent from informed consent form
* Inadequate buccal swab (sample may be collected twice)
Treatments Being Tested
DIAGNOSTIC_TEST
whole genome sequencing
whole genome sequencing of genomic DNA extracted from buccal swab
Locations (20)
Centro de Pesquisa Silvestre Santé
Rio Branco, Acre, Brazil
Centro de Pesquisas Clínicas Dr. Marco Mota
Maceió, Alagoas, Brazil
Hospital Universitário da Unifap
Macapá, Amapá, Brazil
Hospital de Messejana Dr. Carlos Alberto Studart Gomes
Fortaleza, Ceará, Brazil
Hospital Universitário Professor Edgard Santos
Salvador, Estado de Bahia, Brazil
Hospital Ana Nery - HAN/SESAB
Salvador, Estado de Bahia, Brazil
Instituto de Cardiologia e Transplantes do Distrito Federal
Brasília, Federal District, Brazil
Hospital das Clínicas da Universidade Federal de Goiás - HC-UFG
Goiânia, Goiás, Brazil
Universidade Ceuma
São Luís, Maranhão, Brazil
Hospital Felicio Rocho - HFR
Belo Horizonte, Minas Gerais, Brazil
Liga Mineira de Ressuscitação Cardiopulmonar
Belo Horizonte, Minas Gerais, Brazil
Santa Casa de Misericórdia de Montes Claros
Montes Claros, Minas Gerais, Brazil
Health & Care
Belém, Pará, Brazil
Hospital Universitário Pedro Ernesto - UERJ
Rio de Janeiro, Rio de Janeiro, Brazil
Instituto de Puericultura e Pediatria Martagão Gesteira
Rio de Janeiro, Rio de Janeiro, Brazil
Hospital Universitário Clementino Fraga Filho - UFRJ
Rio de Janeiro, Rio de Janeiro, Brazil
Instituto Nacional de Cardiologia
Rio de Janeiro, Rio de Janeiro, Brazil
Hospital Universitário Onofre Lopes - UFRN
Natal, Rio Grande do Norte, Brazil
Hospital das Clínicas de Porto Alegre - UFRGS
Porto Alegre, Rio Grande do Sul, Brazil
Instituto de Cardiologia - Fundação Universitária de Cardiologia de Porto Alegre - IC-FUC
Porto Alegre, Rio Grande do Sul, Brazil