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RECRUITINGOBSERVATIONAL

Predicting Appendicular Lean and Fat Mass With Bioelectrical Impedance Analysis Among Adult Patients With Obesity.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study aims to develop and cross-validate novel bioelectrical impedance analysis (BIA) equations for predicting appendicular soft tissue masses, specifically fat mass (FM) and appendicular lean mass (ALM), in a sample of Caucasian adult subjects affected by obesity. The research will compare these new BIA equations with three established BIA-derived prediction models and validate them using dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging (MRI) data. This study utilizes existing datasets to enhance the accuracy and applicability of BIA in assessing body composition and supports the development of standardized algorithms for converting raw BIA data across different devices and populations.

Who May Be Eligible (Plain English)

Who May Qualify: - Adults with obesity (BMI ≥ 30 kg/m²) - Age 18 years and older - Available baseline DXA and BIA measurements - Provided willing to sign a consent form for data use Who Should NOT Join This Trial: - any chronic disease or medication that can significantly affect body composition \[eg. malignant diseases in the last 5 years, organ failure, acute inflammation (C-reactive protein\>10 mg/L) autoimmune conditions (where your immune system attacks your own body)s, neurological diseases, syndromic obesity\] - cognitive impairment (Mini-Mental State Examination \<25) - subjects that are considered physically active (athletes or very active subjects i.e., performing at least 150 minutes of moderate to vigorous physical activity per week) - alcohol intake \>140g/wk for Males and 70g/wk for Females - participation in a weight-reducing program (last 3 months) - impossibility to perform DXA exam - pregnancy and breast-feeding. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Adults with obesity (BMI ≥ 30 kg/m²) * Age 18 years and older * Available baseline DXA and BIA measurements * Provided informed consent for data use Exclusion Criteria: * any chronic disease or medication that can significantly affect body composition \[eg. malignant diseases in the last 5 years, organ failure, acute inflammation (C-reactive protein\>10 mg/L) autoimmune diseases, neurological diseases, syndromic obesity\] * cognitive impairment (Mini-Mental State Examination \<25) * subjects that are considered physically active (athletes or very active subjects i.e., performing at least 150 minutes of moderate to vigorous physical activity per week) * alcohol intake \>140g/wk for Males and 70g/wk for Females * participation in a weight-reducing program (last 3 months) * impossibility to perform DXA exam * pregnancy and breast-feeding.

Locations (9)

Pennington Biomedical Research Center, Louisiana State University
Baton Rouge, Louisiana, United States
Division of Geriatric Medicine, School of Medicine, and Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Curtin University, School of Population Health
Perth, Australia
Federal University of Pelotas
Pelotas, Rio Grande do Sul, Brazil
University of Alberta, Department of Agricultural, Food and Nutritional Science
Edmonton, Alberta, Canada
University of Cagliari, Department of Life and Environmental Sciences
Cagliari, Italy
Sapienza, University of Rome
Roma, Italy
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
Trieste, Italy
Universidade de Lisboa, Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana
Lisbon, Portugal