Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs

Who May Qualify: - Age ≤ 18 years at time of transplant listing - Subject is within 10-50 days post-orthotopic heart transplant at time of enrollment. - Planned follow-up at the transplant center for a minimum of one-year. - Caregiver able and willing to comply with the study visit schedule, study procedures, and study requirements. Who Should NOT Join This Trial: - Recipient of a multi-organ transplant - History of prior solid organ transplant before the index heart transplant - Ongoing mechanical circulatory support or hemodynamic instability after transplant - Active infection requiring either a) hospitalization or b) treatment with antimicrobial drugs (does not include prophylaxis for infection or suppressive antibiotics given after transplant) - History of treated rejection prior to study enrollment - Inability to collect specified blood volume after enrollment and prior to 50 days post-transplant Always talk to your doctor about whether this trial is right for you.