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RECRUITINGINTERVENTIONAL

Developing a Treatment Clustering System for Obstructive Sleep Apnea Using Polysomnographic Physiological Signals

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Obstructive sleep apnea syndrome (OSA) is marked by repeated upper airway obstructions during sleep, affecting approximately 14% of men and 5% of women aged 30-70 years. However, precise clinical prediction tools for selecting optimal treatment strategies are lacking. This study aims to develop an automated treatment clustering system using artificial intelligence to classify patients based on etiology into (i) anatomical factors, (ii) reduced muscle responsiveness, and (iii) other non-anatomical factors. This system will analyze physiological sleep assessments, such as electromyography (EMG) and pneumotachographs, from a retrospective polysomnography (PSG) database. Cross-validation will be conducted on new OSA patients undergoing various management strategies, including surgical intervention, CPAP therapy, and oropharyngeal training (delivered face-to-face or via telerehabilitation). This system aims to enhance clinicians' ability to predict treatment success rates and improve patient outcomes.

Who May Be Eligible (Plain English)

Who May Qualify: - OSA patients - Aged over 20 years Who Should NOT Join This Trial: - BMI≧ 32 - Central or mixed types of sleep apnea - A history of malignancy or infection of the head and neck region and laryngeal trauma - Craniofacial malformation - Stroke - Neuromuscular disease - Severe cardiovascular disease - Active psychiatric disease - Structural abnormalities over the upper respiratory airway - Performed any operation or treatment over the neck before - Pregnancy Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * OSA patients * Aged over 20 years Exclusion Criteria: * BMI≧ 32 * Central or mixed types of sleep apnea * A history of malignancy or infection of the head and neck region and laryngeal trauma * Craniofacial malformation * Stroke * Neuromuscular disease * Severe cardiovascular disease * Active psychiatric disease * Structural abnormalities over the upper respiratory airway * Performed any operation or treatment over the neck before * Pregnancy

Treatments Being Tested

OTHER

Control Group

sleep hygiene education

PROCEDURE

Surgical Intervention

Surgical Intervention includes uvulopalatopharyngoplasty (UPPP) and transoral robotic surgery (TORS). UPPP involves the removal of the uvula and tonsils, while TORS consists of the removal of the uvula, tonsils, and adipose tissue at the base of the tongue.

OTHER

Oropharyngeal Training (face-to-face)

Participants will attend face-to-face oropharyngeal training sessions with a therapist in the lab, each lasting 45-60 minutes, 1-2 times per week, over a 12-week intervention period.

OTHER

Oropharyngeal Training (telerehabilitation)

Participants will attend online oropharyngeal training (telerehabilitation) sessions with a therapist, each lasting 45-60 minutes, 1-2 times per week, over a 12-week intervention period.

DEVICE

Continuous Positive Airway Pressure

Participants will use Continuous Positive Airway Pressure (CPAP) throughout the intervention period.

Locations (1)

National Cheng Kung University Hospital
Tainan, Taiwan