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RECRUITINGINTERVENTIONAL

Strokectomy in Malignant Cerebral Media Infarction

Strokectomy in Malignant Cerebral Media Infarction: A Pilot Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Decompressive hemicraniectomy (DC) is the standard procedure and life saving measure in case of malignant middle cerebral artery (MCA) infarction. However, there have been several studies reporting the neuroinflammatory cascade based on the necrotic tissue as one of the leading cause for the secondary brain damage, wherefore, strokectomy with resection of necrotic tissue has been proposed in some case series as an alternative surgical option. Thus, the aim of this study is to perform a pilot study by including patients with malignant MCA infarction and to check the feasibility of this specific surgical treatment.

Who May Be Eligible (Plain English)

Who May Qualify: - 18 years of age or older - Ischemic middle cerebral artery (MCA) infarction at least two thirds of the MCA territory - Clinical symptoms of acute unilateral MCA infarction less than 48 hours prior to the initiation of treatment Who Should NOT Join This Trial: - Preexisting modified Rankin Scale \>2 - Absence of pupillary reflexes or GCS \<6 - Intracerebral hemorrhage or other associated brain lesions - Contraindications for surgery - Estimated life expectancy of less than 3 years Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * 18 years of age or older * Ischemic middle cerebral artery (MCA) infarction at least two thirds of the MCA territory * Clinical symptoms of acute unilateral MCA infarction less than 48 hours prior to the initiation of treatment Exclusion Criteria: * Preexisting modified Rankin Scale \>2 * Absence of pupillary reflexes or GCS \<6 * Intracerebral hemorrhage or other associated brain lesions * Contraindications for surgery * Estimated life expectancy of less than 3 years

Treatments Being Tested

PROCEDURE

Strokectomy/Necrosectomy

After obtaining CT-/MRT-perfusion, the infarcted area (e.g. infarct core) of malignant MCA-infarction is localized. By using the neuronavigation, surgical resection of necrotic tissue is performed in a non-eloquent area until the space occupying effect is released. At the end of the surgery, the bone flap is reinserted and fixated.

Locations (1)

University Medical Center Rostock
Rostock, Mecklenburg-Vorpommern, Germany