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RECRUITINGOBSERVATIONAL

Changes in Attentional Control After a Focal Seizure.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.

Who May Be Eligible (Plain English)

Who May Qualify: - Age superior to 18 and under 80 - Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up - Normal global cognitive performance (standard progressive Raven matrices score \> 5th percentile) - Be affiliated to the social security system - Have signed an willing to sign a consent form Who Should NOT Join This Trial: - Pregnancy or breastfeeding - Not able to give consent (Article 1121-8 of the CSP) - Vulnerable person - Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) - Guardianship - Have a high probability of not respecting the protocol or of abandoning the study - Absence of any epileptic seizure recorded during the hospitalization - Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age superior to 18 and under 80 * Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up * Normal global cognitive performance (standard progressive Raven matrices score \> 5th percentile) * Be affiliated to the social security system * Have signed an informed consent Exclusion Criteria: * Pregnancy or breastfeeding * Not able to give consent (Article 1121-8 of the CSP) * Vulnerable person * Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP) * Guardianship * Have a high probability of not respecting the protocol or of abandoning the study * Absence of any epileptic seizure recorded during the hospitalization * Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.

Treatments Being Tested

OTHER

All included subjects

Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.

Locations (1)

University Hospital,
Lille, France