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RECRUITINGINTERVENTIONAL

Predictive Value of the Optic Nerve Involvement in Clinically Isolated Syndrome

Evaluation of the Predictive Value of the Optic Nerve Involvement at the Stage of Clinically Isolated Syndrome, for the Diagnosis of Clinically Definite Multiple Sclerosis and the Delay of Second Relapses' Occurrence

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Optic neuritis (ON) represents around 30% of clinical presentation of clinically isolated syndrome (CIS). Asymptomatic optic nerve involvement is very frequent in all stage of multiple sclerosis (MS) disease including the CIS. However, optic nerve is still not part of MS diagnosis criteria. The main objective of our regional and multicenter study is to evaluate the prognostic value of optic nerve involvement at the earliest clinical stage of MS (=CIS) for the diagnosis of clinically definite MS (2nd clinical relapse) and the delay until the 2nd relapse.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients between 18 and 55 years old - Occurrence of CIS ≤ 6 months - With two T2 hypersignals on brain/spinal cord MRI suggestive of MS or with oligoclonal bands - Giving their written willing to sign a consent form Who Should NOT Join This Trial: - Pathological conditions that may skew the optic nerve MRI and/or retinal OCT (diabetes mellitus, glaucoma, retinopathy, ametropia \>6 dioptria) - Past history of MS relapses - Extensive myelitis (\>3 vertebral bodies) - Bilateral optic neuritis without T2 lesions suggestive of MS - Contra-indication to MRI, gadolinium injection - Pregnancy, breast-feeding - Patients unable to consent Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients between 18 and 55 years old * Occurrence of CIS ≤ 6 months * With two T2 hypersignals on brain/spinal cord MRI suggestive of MS or with oligoclonal bands * Giving their written informed consent Exclusion Criteria: * Pathological conditions that may skew the optic nerve MRI and/or retinal OCT (diabetes mellitus, glaucoma, retinopathy, ametropia \>6 dioptria) * Past history of MS relapses * Extensive myelitis (\>3 vertebral bodies) * Bilateral optic neuritis without T2 lesions suggestive of MS * Contra-indication to MRI, gadolinium injection * Pregnancy, breast-feeding * Patients unable to consent

Treatments Being Tested

OTHER

Optic nerve MRI sequence

Systematic optic nerve MRI sequence during the CIS diagnosis work-up. This sequence is not done systematically and not recommended for now (except in case of acute ON). The interventional nature of the study remains minimal

Locations (1)

Hôpital Roger Salengro
Lille, France