Use of a Freeze-dried Amniotic Membrane Post Crosslinking in Subjects With Progressive Keratoconus

Who May Qualify: - Man or woman between 18 and 65 years old. - Indication for accelerated conventional crosslinking. - Patient with progressive keratoconus (increase in Kmax of ≥ 0.5 diopters in 3 to 6 months or ≥ 1 diopter in 3 to 12 months with loss of 10 microns on minimum pachymetry in 3 to 12 month). - Patient suffering from keratoconus with a compatible topographic form (Kmax ≥ 47.0 diopters (D) and difference inferior-superior of 1.5 D). - Patient with a minimum corneal thickness greater than 400 microns. - Informed and consenting patient. - Patient physically and mentally capable of completing the post-operative pain assessment self-questionnaire. - Patient having signed the willing to sign a consent form of the French Ophthalmology Society for crosslinking. - Patient affiliated to a social security system or beneficiary of such a system. Who Should NOT Join This Trial: - Woman without effective means of contraception, pregnant or breastfeeding. - Patient who has already benefited from a crosslinking procedure on one of the eyes. - Patient with a history of refractive surgery on one of the eyes. - Patient with an intracorneal ring segment on one of the eyes. - Patient suffering from a serious systemic pathology (autoimmune and/or immunodepressive) - Patient with a psychiatric pathology. - Patient on long-term analgesics and/or corticosteroids. - Indication of crosslinking outside the classic protocol. - Patient with central corneal opacity. - Patient suffering from a severe dry eye syndrome or a neurotrophic keratitis. - Patient with a history of ocular herpes. - Patient with a history of ocular varicella-zoster virus infection. - Patient with glaucoma. - Patient treated with topical cyclosporine in the last 6 months. - Patient deprived of liberty by a judicial or administrative decision. - Patient subject to a legal protection measure or unable to express their consent. Always talk to your doctor about whether this trial is right for you.