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RECRUITINGOBSERVATIONAL

Multimodal Assesment of Alzheimer Patients

Multimodal Assessment of Cognitive Impairment in Alzheimer Patients

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this study is to learn more about the changes in the brains of patients with cognitive impairment (MCI) and Alzheimer's Disease (AD). The main questions the study aims to answer are: 1. What findings can be used to earlier detect patients that will develop Alzheimers? 2. Which differences are seen between healthy and cognitively impaired patients? 3. Which differences are seen between patients with Alzheimers disease? Participants will undergo: * Cognitive tests * Magnetic resonance imaging (MRI) * Electroencephalography (EEG) * Blood sample collection * Fecal sample collection * A randomized group will undergo polysomnography analysis.

Who May Be Eligible (Plain English)

Who May Qualify: - MCI and AD according to relevant ICD-criterias. - Control cohort is age and gender matched with other cohorts. Who Should NOT Join This Trial: - Uneligibility for any of the planned neuroimagery devices (MRI, EEG) - AD diagnosis before the age of 65 (Early-onset AD). - Brain tumor - Traumtic head injury - Earlier neurosurgery - Other neyrodegenerative diseases (i.e Parkinson and ALS) - Diseases related to inflammation and auto-immunity (i.e MS) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * MCI and AD according to relevant ICD-criterias. * Control cohort is age and gender matched with other cohorts. Exclusion Criteria: * Uneligibility for any of the planned neuroimagery devices (MRI, EEG) * AD diagnosis before the age of 65 (Early-onset AD). * Brain tumor * Traumtic head injury * Earlier neurosurgery * Other neyrodegenerative diseases (i.e Parkinson and ALS) * Diseases related to inflammation and auto-immunity (i.e MS)

Treatments Being Tested

DEVICE

MRI Scanning

MRI scanning with volumetric, resting and activity-based sequences.

DEVICE

64-channel EEG

EEG to quantifiy electric activity.

DEVICE

Polysomnography

A randomized group will undergo polysomnography.

BIOLOGICAL

Blood samples

Analysis of specific blood biomarkers.

BIOLOGICAL

Fecal samples

Analysis of bacterial composition.

BEHAVIORAL

Cognitive tests

Interview-based cognitive tests for assesment of cognitive levels.

Locations (1)

Norwegian University of Sciene and Technology / Norges teknisk-naturvitenskapelige universitet (NTNU)
Trondheim, Trønderlag, Norway