INSPIRE: a Multi-Cancer Early Detection Study

Inclusion Criteria for Case Arm Participants: - 40-75 years old - Clinically and/or pathologically diagnosed cancer - No prior or undergoing any systemic or local antitumor therapy, including but not limited to surgical resection, radiochemotherapy, endocrinotherapy, targeted therapy, immunotherapy, interventional therapy, etc. - Able to provide a written willing to sign a consent form and willing to comply with all part of the protocol procedures Exclusion Criteria for Case Arm Participants: - Pregnancy or lactating women - Known prior or current diagnosis of other types of malignancies comorbidities - Have participated in an "interventional" clinical trial within the past 30 days and have taken the experimental drug; - Recipients of organ transplant or prior bone marrow transplant or stem cell transplant - Recipients of blood transfusion within 30 days prior to screen - Recipients of therapy in past 14 days prior to screen, including oral or IV antibiotics, glucocorticoid, azacitidine, decitabine, procainamide, hydrazine, arsenic trioxide - Failure to collect blood on time according to plan - The blood sample does not meet the requirements Inclusion Criteria for Control Arm Participants: - 40-75 years old - Without confirmed cancer diagnosis - Able to provide a written willing to sign a consent form and willing to comply with all part of the protocol procedures Exclusion Criteria for Control Arm Participants: - Pregnancy or lactating women - No previous history of malignancy in other sites - Recipients of organ transplant or prior bone marrow transplant or stem cell transplant - Recipients of blood transfusion within 30 days prior to screen - Recipients of therapy in the past 14 days prior to screen, including oral or IV antibiotics, glucocorticoid, azacitidine, decitabine, procainamide, hydrazine, arsenic trioxide - Unsuitable for this trial determined by the researchers Always talk to your doctor about whether this trial is right for you.