RECRUITINGINTERVENTIONAL

Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis

About This Trial

The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants: * healthy volunteers * patients with early Parkinson's disease * patients with incipient Lewy body disease. To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data. This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.

Who May Be Eligible (Plain English)

Who May Qualify: Healthy volunteers: - Person who has given written consent - Adult - Enrolled in the national register of healthy volunteers - Fasting \> 2 hours before PEG measurement - Body Mass Index (BMI) \< 30 kg/m². - No cognitive complaints and normal neurological assessment Patients with idiopathic Parkinson's disease: - Person who has given written consent - Adult - Fasting \> 2 hours before PEG measurement - Body Mass Index (BMI) \< 30 kg/m². - Diagnostic criteria for established or probable IPD Patients with Lewy body disease: - Person who has given written consent - Adult - Fasting \> 2 hours prior to PEG measurement - Body Mass Index (BMI) \< 30 kg/m². - Diagnostic criteria for probable or possible LBD Who Should NOT Join This Trial: - Non-affiliated to national health insurance - Person under legal protection (curatorship, guardianship) - Person subject to a court order - Pregnant, parturient or breast-feeding women - Major unable to give consent - MMSE score \< 15 and/or MoCA \< 10 - Known infection with COVID-19 in the 6 months prior to inclusion - Active smoker (\> 4 cigarettes per day on a regular basis) - Subject with pacemaker (contraindication for bioelectrical impedancemetry) - Diabetic (type 1 or type 2) - Taking medication (in progress at the time of the study) that interferes with gustation Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: Healthy volunteers: * Person who has given written consent * Adult * Enrolled in the national register of healthy volunteers * Fasting \> 2 hours before PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * No cognitive complaints and normal neurological assessment Patients with idiopathic Parkinson's disease: * Person who has given written consent * Adult * Fasting \> 2 hours before PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * Diagnostic criteria for established or probable IPD Patients with Lewy body disease: * Person who has given written consent * Adult * Fasting \> 2 hours prior to PEG measurement * Body Mass Index (BMI) \< 30 kg/m². * Diagnostic criteria for probable or possible LBD Exclusion Criteria: * Non-affiliated to national health insurance * Person under legal protection (curatorship, guardianship) * Person subject to a court order * Pregnant, parturient or breast-feeding women * Major unable to give consent * MMSE score \< 15 and/or MoCA \< 10 * Known infection with COVID-19 in the 6 months prior to inclusion * Active smoker (\> 4 cigarettes per day on a regular basis) * Subject with pacemaker (contraindication for bioelectrical impedancemetry) * Diabetic (type 1 or type 2) * Taking medication (in progress at the time of the study) that interferes with gustation

Treatments Being Tested

BIOLOGICAL

Fasting blood test

metabolic assays determination of food intake hormones oxidative stress and neurodegeneration marker assays

OTHER

Subject interview

socio-demographic data, medical and family history, treatment taken

OTHER

Motor assessment

MDS-UPDRS scale PART III

OTHER

Neurocognitive assessment

MoCA and MMSE scales

OTHER

Nutritional assessment

anthropometric data (weight, height, BMI, waist circumference, hip circumference, android/gynoid ratio, triceps skin fold, brachial circumference), bioelectrical impedancemetry (fat mass, lean mass, water mass and bone mass)

OTHER

Taste tests

Recording of PEGs in response to a sucrose solution and a free fatty acid solution (prepared beforehand)

Locations (1)

Chu Dijon Bourgogne

Dijon, France