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RECRUITINGINTERVENTIONAL

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The purpose of this study is to determine if the Fractionated Laser Resurfacing (FLR) procedure can protect one forearm/wrist from precancerous actinic keratosis (AKs) as well as prevent skin cancer in older subjects with active AKs. This study builds on a similar study ongoing at the Dayton Veterans Administration dermatology clinic. This study is also testing if a photograph of the skin can be used to predict where the AKs and an skin cancers will form.

Who May Be Eligible (Plain English)

Who May Qualify: - Adult Males and Females aged 60 and older - Have at least 5 AKs on each forearm/wrist, but no more than 10 to allow for easy monitoring - Skin type fair (Fitzpatrick I-II) - Females must be post-menopausal and not be on systemic hormone replacement therapy - Able to comprehend procedures and risks Who Should NOT Join This Trial: - More than 10 AKs on an extremity - AKs that are large (2-3+, hyperkeratotic grade 3 lesions) - AKs that are very thick (\>3 mm) - Medical history of diabetes - History of poor wound healing or scarring - Large tattoos that can interfere with study - Other serious health issues and other skin diseases that could interfere with the study - Recent (within 1 year) field therapies such as efudex cream or PDT to forearms/wrists. - Planning to leave region in next 5 years - Subjects with allergies to xylocaine will be excluded if they need this topical anesthetic. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Adult Males and Females aged 60 and older * Have at least 5 AKs on each forearm/wrist, but no more than 10 to allow for easy monitoring * Skin type fair (Fitzpatrick I-II) * Females must be post-menopausal and not be on systemic hormone replacement therapy * Able to comprehend procedures and risks Exclusion Criteria: * More than 10 AKs on an extremity * AKs that are large (2-3+, hyperkeratotic grade 3 lesions) * AKs that are very thick (\>3 mm) * Medical history of diabetes * History of poor wound healing or scarring * Large tattoos that can interfere with study * Other serious health issues and other skin diseases that could interfere with the study * Recent (within 1 year) field therapies such as efudex cream or PDT to forearms/wrists. * Planning to leave region in next 5 years * Subjects with allergies to xylocaine will be excluded if they need this topical anesthetic.

Treatments Being Tested

DEVICE

Fractionated Laser Resurfacing

A rejuvenating laser that makes tiny holes in the very superficial part of the skin.

Locations (1)

Wright State Physicians
Fairborn, Ohio, United States