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RECRUITINGINTERVENTIONAL

FAPI and FDG PET/MRI in Diagnosis and Therapy Prediction of Bladder Cancer

Application Research of FAPI Positron Emission Tomography(PET)/MRI, 18F-Fluorodeoxyglucose (FDG) PET/MRI, and MRI in the Diagnosis of Muscular Invasive Bladder Cancer and Evaluation of Neoadjuvant Therapy Efficacy

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of this trial is to investigate the value of FAPI PET/MRI, FDG PET/MRI and MRI in diagnosing MIBC and predicting the efficacy of neoadjuvant therapy for MIBC patients, so as to guide the clinic to adjust the treatment plan in time and benefit MIBC patients.

Who May Be Eligible (Plain English)

Who May Qualify: - Inclusion criteria for MIBC diagnostic studies 1. Patients with suspected muscle-invasive bladder cancer; 2. Completion of FAPI PET/MRI, FDG PET/MRI and MRI; 3. Complete clinical laboratory and pathological data. - Inclusion criteria for MIBC neoadjuvant therapy efficacy evaluation study 1. Patients diagnosed with muscle invasive bladder cancer; 2. Completion of FAPI PET/MRI, FDG PET/MRI, and MRI before neoadjuvant therapy; 3. Complete clinical laboratory and pathological data. Who Should NOT Join This Trial: - Exclusion criteria for MIBC diagnostic study 1. Combined with other malignant tumors; 2. Not receiving surgical treatment; 3. Receiving neoadjuvant therapy before surgery; 4. Previous allergy to contrast components or similar components; 5. Serious organ function abnormalities, such as heart, lung, liver, kidney function serious abnormalities; 6. Incomplete clinicopathological data - Exclusion criteria of MIBC neoadjuvant therapy efficacy evaluation study 1. Combination of other malignant tumors; 2. FAPI PET/MRI, FDG PET/MRI and MRI were not completed after neoadjuvant therapy; 3. Prior hypersensitivity to contrast components or similar components; 4. Serious organ function abnormalities, such as serious abnormalities of heart, lung, liver and kidney function; 5. Incomplete clinicopathological data. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Inclusion criteria for MIBC diagnostic studies 1. Patients with suspected muscle-invasive bladder cancer; 2. Completion of FAPI PET/MRI, FDG PET/MRI and MRI; 3. Complete clinical laboratory and pathological data. * Inclusion criteria for MIBC neoadjuvant therapy efficacy evaluation study 1. Patients diagnosed with muscle invasive bladder cancer; 2. Completion of FAPI PET/MRI, FDG PET/MRI, and MRI before neoadjuvant therapy; 3. Complete clinical laboratory and pathological data. Exclusion Criteria: * Exclusion criteria for MIBC diagnostic study 1. Combined with other malignant tumors; 2. Not receiving surgical treatment; 3. Receiving neoadjuvant therapy before surgery; 4. Previous allergy to contrast components or similar components; 5. Serious organ function abnormalities, such as heart, lung, liver, kidney function serious abnormalities; 6. Incomplete clinicopathological data * Exclusion criteria of MIBC neoadjuvant therapy efficacy evaluation study 1. Combination of other malignant tumors; 2. FAPI PET/MRI, FDG PET/MRI and MRI were not completed after neoadjuvant therapy; 3. Prior hypersensitivity to contrast components or similar components; 4. Serious organ function abnormalities, such as serious abnormalities of heart, lung, liver and kidney function; 5. Incomplete clinicopathological data.

Treatments Being Tested

PROCEDURE

imaging examinations:FAPI PET/MRI, FDG PET/MRI, MRI

FAPI PET/MRI and FDG PET/MRI examination Data acquisition was performed using a GE Healthcare SIGNA PET/MR instrument. Enrolled patients were injected intravenously with 68Ga-FAPI or 18F-FDG tracer and underwent simultaneous PET and MRI scanning approximately 30-60 minutes after intravenous administration of the tracer at a dose of 1.85-3.7 MBq/kg. MRI examination MRI examination was performed using a Skyra 3.0T MRI scanner from Siemens, Germany, with a 16-channel phased-array surface coil, and the scanning range was from the superior margin of the iliac wing to the inferior margin of the pubic symphysis.

Locations (1)

first hospital affiliated of Fujian medical university
Fuzhou, Fujian, China