RECRUITINGINTERVENTIONAL
Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect
About This Trial
The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).
Who May Be Eligible (Plain English)
Who May Qualify:
- Diagnosed with ALS in the last 6 months according to Gold Coast Criteria
Who Should NOT Join This Trial:
- \- Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and/or tablet, or through telephone interview.
- Lack of ability to cooperate.
- Pregnancy
- Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics.
- Alcohol addiction defined as over 21 units weekly.
- Lesional neurological diseases, such as stroke, tumor or multiple sclerosis
- Epilepsy
- Neurodegenerative diseases other than ALS
- Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia
- Contraindication for MRI and MEG scan according to hospital guidelines
- Severe liver or kidney disease
- Dysregulated heart disease
- Ongoing treatment with any antidepressants or any antipsychotics at recruitment.
- Diagnosed with frontotemporal dementia.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Diagnosed with ALS in the last 6 months according to Gold Coast Criteria
Exclusion Criteria:
* \- Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and/or tablet, or through telephone interview.
* Lack of ability to cooperate.
* Pregnancy
* Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics.
* Alcohol addiction defined as over 21 units weekly.
* Lesional neurological diseases, such as stroke, tumor or multiple sclerosis
* Epilepsy
* Neurodegenerative diseases other than ALS
* Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia
* Contraindication for MRI and MEG scan according to hospital guidelines
* Severe liver or kidney disease
* Dysregulated heart disease
* Ongoing treatment with any antidepressants or any antipsychotics at recruitment.
* Diagnosed with frontotemporal dementia.
Treatments Being Tested
OTHER
Diffusion Kurtosis Imaging (DKI)
Non-invasive MRI sequence which extracts information of diffusion signals from complex brain tissue
OTHER
Resting State Magnetoencephalography
Non-invasive method of measuring resting state brain activity through magnetoencephalography (MEG)
Locations (1)
Aalborg University hospital
Aalborg, Northern Jutland, Denmark