Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Inclusion/Who Should NOT Join This Trial: - Bipolar disorder diagnosis: Patients must have a Diagnostic Statistical Manual (DSM)-V diagnosis of bipolar disorder on the Structured Clinical Interview for DSM (SCID) - Bipolar disorder symptoms: Patients must be stable and euthymic at time of consent and testing, documented by no hospitalizations in the prior 4 weeks - Age: between 18-45 yrs for patients with bipolar disorder and age-matched controls - Weight does not exceed 350lbs. - Diameter does not exceed 60 cm when supine - HbA1C \< 7% - No non-MRI-compatible metal in the body (e.g., pacemaker, shrapnel, joint pins) - No claustrophobia - No history of significant head injury - No history of electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS) within the last 3 months - No history of previous treatment with following procedures: vagus nerve stimulation, or deep brain stimulation - Are not deemed a serious suicide or homicide risk - No unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurological, or hematological disease - No seizure disorders - Have the capacity to sign willing to sign a consent form - No current diagnosis or history of an alcohol or substance use disorder in the last 6 months or positive test for an illicit drug on the screening urine analysis (positive cannabis screen is not exclusionary): confirmed using urine toxicology test during the initial screening visit and before each MRI scan visit. - For Healthy Volunteers Only: No psychotropic medication and no history of neurological disease - Must have vision that is 20/20 or correctable to 20/20 with contact lenses - No Type 1 diabetes mellitus - No regular consumption of insulin and other antidiabetics, like Metformin®, GLP1-RA's and others. - No kidney disease, as determined by medical history and/or blood work - No history of heart attack or stroke - No difficulty swallowing - No myxedema ...See full criteria on ClinicalTrials.gov Always talk to your doctor about whether this trial is right for you.