RECRUITINGINTERVENTIONAL

Platelet-Rich Plasma Injection Versus Hydrodissection in the Treatment of Carpal Tunnel Syndrome

A Prospective Comparative Study on the Efficacy of Ultrasound-Guided Platelet-Rich Plasma Injection Versus Hydrodissection in the Treatment of Carpal Tunnel Syndrome

About This Trial

The goal of this clinical trial is to compare the efficacy of Ultrasound-Guided Platelet-Rich Plasma Injection versus Hydrodissection (using 2ml saline, 2ml dexamethasone and 1ml lidocaine) in the Treatment of Carpal Tunnel Syndrome. The main questions it aims to answer are: * Which modality is more effective in reducing symptoms and improving function in patients with Carpal tunnel syndrome * Asses safety profile of both methods Participants will: * Randomized to one of the two arms * Visit the clinic 1 and 3 months after intervention * Assessed for efficacy and safety of the intervention

Who May Be Eligible (Plain English)

Who May Qualify: - Patients diagnosed clinically as carpal tunnel syndrome with at least 3 months of symptoms and confirmed electro-physiologically as carpal tunnel syndrome Who Should NOT Join This Trial: - Onset of carpal tunnel syndrome during pregnancy - Co-existence of brachial plexopathy or thoracic outlet syndrome by clinical examination - Previous carpal tunnel decompressive surgery or corticosteroid injection in carpal tunnel - Patients with infection or local edema at the site of injection. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Patients diagnosed clinically as carpal tunnel syndrome with at least 3 months of symptoms and confirmed electro-physiologically as carpal tunnel syndrome Exclusion Criteria: * Onset of carpal tunnel syndrome during pregnancy * Co-existence of brachial plexopathy or thoracic outlet syndrome by clinical examination * Previous carpal tunnel decompressive surgery or corticosteroid injection in carpal tunnel * Patients with infection or local edema at the site of injection.

Treatments Being Tested

OTHER

ultrasound guided PRP injection

whole blood is initially collected in tubes that contain anticoagulants, such as citrate dextrose A to prevent platelet activation prior to its use. Then PRP is prepared by a differential centrifugation. Then 3ml of PRP will be delivered via the in-plane ulnar approach

OTHER

ultrasound guided hydrodissection

5ml will be injected to detach the median nerve from the TCL (2ml saline, 2ml dexamethasone and 1ml lidocaine), the injectate will be delivered via the in-plane ulnar approach, and the median nerve will be hydrodissected from its undersurface while advancing the needle among the superficial surface of the median nerve and the TCL

Locations (1)

Mansoura University

Al Mansurah, Egypt