Screening for AL Amyloidosis in Smoldering Multiple Myeloma

Who May Qualify: - Patients 40 years of age and older - diagnosed with either Smoldering Multiple Myeloma or a Monoclonal Gammopathy - dFLC greater than 23 mg/L - abnormal FLC ratio - If the patient has an eGFR less than 50 mL/min/1.73m2, the FLC ratio is inconsequential. The patient only needs to meet the age and dFLC criterion. Who Should NOT Join This Trial: - Patients younger than 40 years of age are not eligible - Patients with a previous finding of amyloid in other biopsies will not be included - Adults unable to consent are not eligible, including the cognitively impaired Pregnant women, pregnant minors, minors (i.e., individuals who are not yet adults), wards of the state, non-viable neonates, neonates of uncertain viability, and prisoners are not eligible Always talk to your doctor about whether this trial is right for you.