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RECRUITINGPhase 4INTERVENTIONAL

Intravesical Gentamicin to Prevent Recurrent UTI

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Feasibility assessment of intravesical gentamicin instillation (putting antibiotics directly into the bladder) versus the current standard of care of oral nitrofurantoin prophylaxis (taking a low dose of antibiotics by mouth every day) to prevent recurrent urinary tract infections (UTI)

Who May Be Eligible (Plain English)

Who May Qualify: - Postmenopausal - 2 UTIs in 6 months - desire to start antibiotic prophylaxis to prevent UTIs Who Should NOT Join This Trial: - Parkinsons disease - myasthenia gravis - renal failure - liver failure - bladder pain syndrome - multiple negative urine cultures associated with UTI symptoms (\>/= 3) - bladder Botox treatments in the past - treatment planned for UI and prolapse - unevaluated microscopic hematuria - history of kidney stones - no antibiotics within 4 weeks - most recent weight \<40kg (88.18lbs) - surgically altered urinary tract (urinary diversion, phalloplasty, etc) - allergy or hypersensitivity to either of the study medications or medications in the same family including but not limited to: amikacin, kanamycin, neomycin, paromomycin, streptomycin, tobramycin. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion criteria: * Postmenopausal * 2 UTIs in 6 months * desire to start antibiotic prophylaxis to prevent UTIs Exclusion criteria: * Parkinsons disease * myasthenia gravis * renal failure * liver failure * bladder pain syndrome * multiple negative urine cultures associated with UTI symptoms (\>/= 3) * bladder Botox treatments in the past * treatment planned for UI and prolapse * unevaluated microscopic hematuria * history of kidney stones * no antibiotics within 4 weeks * most recent weight \<40kg (88.18lbs) * surgically altered urinary tract (urinary diversion, phalloplasty, etc) * allergy or hypersensitivity to either of the study medications or medications in the same family including but not limited to: amikacin, kanamycin, neomycin, paromomycin, streptomycin, tobramycin.

Treatments Being Tested

DRUG

Gentamicin

administered via bladder

DRUG

Nitrofurantoin

administered PO

Locations (1)

Women & Infants Hospital
Providence, Rhode Island, United States