RECRUITINGOBSERVATIONAL

Natural History Study in Patients with PDE6A-, PDE6B- and RHO-linked Retinitis Pigmentosa

Exploration of New Sensitive Clinical Readouts and Biomarkers That Can Be Used As Clinical Endpoints Tailored to Monitor Treatment Effects in PDE6A-, PDE6B- and RHO-linked Retinitis Pigmentosa: a Non-interventional Trial

About This Trial

The aim of the study is to apply a novel clinical investigation protocol in patients with Phosphodiesterase 6A (PDE6A), PDE6B and Rhodopsin (RHO)-based retinitis pigmentosa. This novel, multimodal clinical examination protocol describes and correlates structural, functional and metabolic aspects during natural disease development. Test-retest variability of new measurements as well as correlations of the structural, functional, and metabolic changes will be defined to be able to define well-suited readouts for safety and efficacy of future treatment developments before they reach the clinical phase.

Who May Be Eligible (Plain English)

Who May Qualify: - Age: from 5 years of age - Patient with PDE6A, PDE6B, and RHO-based retinitis pigmentosa - Patient and/or legal representatives are willing and able to give written willing to sign a consent form Who Should NOT Join This Trial: - severe general disease, that would make longer examinations not possible Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Age: from 5 years of age * Patient with PDE6A, PDE6B, and RHO-based retinitis pigmentosa * Patient and/or legal representatives are willing and able to give written informed consent Exclusion Criteria: * severe general disease, that would make longer examinations not possible

Locations (1)

Institute for Ophthalmic Research, University Tübingen

Tübingen, Baden-Wurttemberg, Germany