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RECRUITINGINTERVENTIONAL

Motor-cognitive Performance in People With Multiple Sclerosis

Motor-cognitive Performance in People With Multiple Sclerosis - Brain Activity and Effects of Balance Exercise

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Having a neurological disease such as multiple sclerosis (MS) leads to difficulties in balance and gait with or without concurrent performance of cognitive tasks, hindering activity performance and influencing the possibilities for an independent lifestyle. The investigators have adapted a previously developed balance training program to a highly challenging program specifically directed to MS (HiBalance-MS). This program was recently tested and found feasible in a pilot study. The investigators will now perform a randomized controlled trial in people with MS, in order to determine the effects of the program. The hypothesis is that progressively challenging balance exercise programs that are specific to the balance control domains affected by MS will be effective to improve balance control, walking, motor-cognitive performance, activity performance and health related quality of life.

Who May Be Eligible (Plain English)

Who May Qualify: - an MS diagnosis according to McDonald criteria; - an overall MS-disability score from 2.0 to 5.5 according to the Expanded Disability Status Scale; - ability to walk 100 m without aid; - a maximum score of 24 in the Mini-BESTest (i.e., \< 25 points) - 18 to 65 years of age Who Should NOT Join This Trial: - cognitive impairment as indicated by a score \<21 in the Montreal Cognitive Assessment; - presence of other conditions that would substantially influence balance; - an MS relapse or change of disease-modifying treatment within the past 8 weeks Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * an MS diagnosis according to McDonald criteria; * an overall MS-disability score from 2.0 to 5.5 according to the Expanded Disability Status Scale; * ability to walk 100 m without aid; * a maximum score of 24 in the Mini-BESTest (i.e., \< 25 points) * 18 to 65 years of age Exclusion Criteria: * cognitive impairment as indicated by a score \<21 in the Montreal Cognitive Assessment; * presence of other conditions that would substantially influence balance; * an MS relapse or change of disease-modifying treatment within the past 8 weeks

Treatments Being Tested

OTHER

HiBalance-MS

See arm description for intervention group.

Locations (1)

Karolinska Institutet
Stockholm, Stockholm County, Sweden