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RECRUITINGINTERVENTIONAL

Resection or Ablation of Small Kidney Tumors

Resection or Ablative Treatment of Small Renal Tumors, a Multicenter Randomized Clinical Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Ablative treatments are believed to have a lower rate of complications, shorter hospital stays, and fewer interventions with benign PAD compared to partial nephrectomies in small kidney cancer lesions. The purpose of the study is to compare complications, the frequency of residual tumors, impact on kidney function, differences in quality of life, and health economic factors in a randomised study. We will also compare the oncological outcomes, including survival and recurrence of kidney cancer.

Who May Be Eligible (Plain English)

Who May Qualify: - Age 18 - 99 years - Patient suitable based on clinical status for both ablative treatment and surgery - Primary kidney tumor - Tumor size ≤ 3 cm - Clinical stage of the tumor T1a (no macroscopic vascular or extrarenal invasion) - Tumor location suitable for both ablative treatment and resection - Absence of radiological signs of metastasis - Biopsy with malignant pathological analysis (PAD) - ISUP grade I-III" Who Should NOT Join This Trial: - Radiological signs of metastasis - Synchronous kidney tumors - ISUP grade IV or sarcomatoid growth in the biopsy - Other metastasized cancer in the last 5 years - Patient unable to make an informed decision to participate in the study Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age 18 - 99 years * Patient suitable based on clinical status for both ablative treatment and surgery * Primary kidney tumor * Tumor size ≤ 3 cm * Clinical stage of the tumor T1a (no macroscopic vascular or extrarenal invasion) * Tumor location suitable for both ablative treatment and resection * Absence of radiological signs of metastasis * Biopsy with malignant pathological analysis (PAD) * ISUP grade I-III" Exclusion Criteria: * Radiological signs of metastasis * Synchronous kidney tumors * ISUP grade IV or sarcomatoid growth in the biopsy * Other metastasized cancer in the last 5 years * Patient unable to make an informed decision to participate in the study

Treatments Being Tested

PROCEDURE

Ablation

Microwave ablation, Radiofrequency ablation, Cryo ablation

PROCEDURE

Surgery

Partial or total nefrectomy

Locations (1)

Karolinska University Hospital
Stockholm, Sweden