Peripheral Extreme Revascularization in "No-option" Patiens With Chronic Limb Threatening Ischemia

Who May Qualify: - Age ≥18 years - Patient has signed an approved willing to sign a consent form form - All patients, with non-revascularizable critical lower limb ischemia defined on the basis of 2 previous unsuccessful Percutaneous Transluminal Angioplasty (PTA) attempts or on severe Medial Artery Calcification (MAC)/Small Artery Disease (SAD) stage. - Patient with Critical Limb Ischaemia, Rutherford category, 5 (minor tissue loss) or 6 (major tissue loss) with active trophic lesions - Ejection Fraction \> 30% Who Should NOT Join This Trial: - Subject no able to perform the follow up or other factors making clinical follow-up difficult - Patients with critical ischaemia of the lower limbs revascularizable by bypass or angioplasty, critical ischaemia characterised by rest pain (Rutherford class ≤ 4) - Ejection Fraction \< 30% Always talk to your doctor about whether this trial is right for you.