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RECRUITINGOBSERVATIONAL

Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729)

A Long-Term Follow-up Study for Subjects With Chronic Hepatitis B Previously Treated With Imdusiran (AB-729)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This is a long term follow-up study for chronic hepatitis B (CHB) subjects who have received imdusiran treatment in a prior clinical trial, stopped NA therapy during that trial, and remain off therapy. Subjects may enroll after completing the end of study visit (baseline visit within 12 weeks ± 1 week from the end of study \[EOS\] visit) from their imdusiran clinical trial (the "parent study"). No interventions will be performed in this study other than blood sample collections, review of current medications, and reporting of any adverse events related to study procedures or NA therapy if restarted. Study participation will be for approximately 2 years (to complete a total of at least 3 years of follow-up while off NA therapy, inclusive of parent study participation).

Who May Be Eligible (Plain English)

Key Who May Qualify: - Have participated in a prior imdusiran clinical trial, - Have discontinued NA therapy in that trial and remain off NA therapy, - Have completed less than 3 years of follow-up visits after NA discontinuation in the parent study. - Have the ability to review and provide signed willing to sign a consent form which includes compliance with all protocol-specified visit schedules and requirements. Who Should NOT Join This Trial: - Not applicable Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Key Inclusion Criteria: * Have participated in a prior imdusiran clinical trial, * Have discontinued NA therapy in that trial and remain off NA therapy, * Have completed less than 3 years of follow-up visits after NA discontinuation in the parent study. * Have the ability to review and provide signed informed consent which includes compliance with all protocol-specified visit schedules and requirements. Exclusion Criteria: * Not applicable

Treatments Being Tested

OTHER

Non-interventional

This is a rollover study

Locations (18)

Research and Education Inc.
San Diego, California, United States
University of Miami Miller School of Medicine
Miami, Florida, United States
Infectious Disease Care
Hillsborough, New Jersey, United States
The Alfred Hospital
Melbourne, Victoria, Australia
Fiona Stanley Hospital
Murdoch, Australia
Prince of Wales Hospital
Shatin, New Territories, Hong Kong
Queen Mary Hospital
Hong Kong, Hong Kong
Arensia Exploratory Medicine Moldova
Chisinau, Moldova
Asan Medial Center
Seoul, South Korea
Changhua Christian Hospital
Changhua, Taiwan
Chia-Yi Christian Hospital
Chiayi City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
E-Da Hospital
Kaohsiung City, Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
Chang Gung Medical Foundation Linkou
Taoyuan District, Taiwan
University Hospital of Wales, Cardiff
Cardiff, United Kingdom
Royal London Hospital
London, United Kingdom
King's College Hospital
London, United Kingdom