Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy

Who May Qualify: 1. Confirmed diagnosis of wtATTR-CM including sequencing of the TTR gene; or HF; or healthy proband without a diagnosis of heart disease 2. Initial diagnosis of respective cardiac disease (wtATTR-CM, HF) after the 6th decade of life; or no cardiac disease (healthy control) 3. Willingness and ability to provide signed willing to sign a consent form form (ICF) 4. Age \> 60 years Who Should NOT Join This Trial: 1. History of severe chronic illness limiting the ability to perform physical activity during the 3rd to 6th decade 2. A diagnosis of dementia or cognitive impairment 3. Any other reason resulting in the inability to perform the questionnaire and/or interview 4. Known disease-causing variant (pathogenic or likely-pathogenic) in the TTR gene Always talk to your doctor about whether this trial is right for you.