RECRUITINGINTERVENTIONAL

In Vitro Organoid Drug Sensitivity-Guided Treatment for Advanced Pancreatic Neuroendocrine Tumor

A Prospective, Exploratory Study Evaluating the Effectiveness of Treatment Regimens for Locally Advanced/Metastatic Non-resectable Pancreatic Neuroendocrine Tumor (PNET) Guided by in Vitro Drug Sensitivity Testing of Tumor Organoids

About This Trial

The purpose of this study is to explore whether chemotherapy and targeted-therapy regimens guided by organoid drug sensitivity test can improve the outcomes of non-resectable locally advanced and metastatic Pancreatic neuroendocrine tumors. At the same time, this study will evaluate the successful stablishment rate of organoid from biopsy tissue , and explore the concordance between drug sensitivity test results and patients' treatment response

Who May Be Eligible (Plain English)

Who May Qualify: 1. Age ≥ 18 and ≤ 75 years old. 2. diagnosed by tissue sample (biopsy-confirmed) locally advanced/metastatic Pancreatic Neuroendocrine Tumor 3. Surgery was considered impossible or can not receive the radical purpose. 4. Able to provide fresh tumor tissue specimens for organoid culture, including: tumor biopsy tissues, tumor surgical specimens, etcy. 5. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score of 0-2. 6. Expected survival time≥ six months. 7. Patient have been informed and consented, compliance and geographic proximity to ensure adequate follow-up Who Should NOT Join This Trial: 1. Other malignancies in the past 5 years, excluding cured basal cell carcinoma of the skin. 2. History of severe cardiovascular events and myocardial Infarction within twelve months before the study. 3. Patients with psychiatric disorders or with psychotropic substance abuse and inability to abstain. 4. Pregnant or breastfeeding women. 5. According to researcher's consideration, patients with other serious systemic diseases or other conditions that are not suitable for participation. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: 1. Age ≥ 18 and ≤ 75 years old. 2. Histologically or cytologically confirmed locally advanced/metastatic Pancreatic Neuroendocrine Tumor 3. Surgery was considered impossible or can not receive the radical purpose. 4. Able to provide fresh tumor tissue specimens for organoid culture, including: tumor biopsy tissues, tumor surgical specimens, etcy. 5. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score of 0-2. 6. Expected survival time≥ six months. 7. Patient have been informed and consented, compliance and geographic proximity to ensure adequate follow-up Exclusion Criteria: 1. Other malignancies in the past 5 years, excluding cured basal cell carcinoma of the skin. 2. History of severe cardiovascular events and myocardial Infarction within twelve months before the study. 3. Patients with psychiatric disorders or with psychotropic substance abuse and inability to abstain. 4. Pregnant or breastfeeding women. 5. According to researcher's consideration, patients with other serious systemic diseases or other conditions that are not suitable for participation.

Treatments Being Tested

OTHER

Chemotherapy and targeted-therapy guided by organoid drug sensitivity test

this study conducts drug sensitivity tests on various clinically approved drugs. The most sensitive drug for the patient is selected for treatment, and the study aims to evaluate the clinical effectiveness of the drug and its consistency with in vitro organoid drug sensitivity.

Locations (1)

Ruijin Hospital Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, China