RECRUITINGINTERVENTIONAL
High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Refractory Epilepsy
The Efficacy, Safety and Mechanism of High Definition Transcranial Direct Current Stimulation (HD-tDCS) in the Treatment of Refractory Epilepsy
About This Trial
To observe the clinical effect and safety of transcranial electrical stimulation on patients with refractory epilepsy before and after treatment and analyze its therapeutic mechanism.
Who May Be Eligible (Plain English)
Who May Qualify:
- Clinical diagnosis of refractory epilepsy
- Right-handed and aged 18-50 years old and primary school education or above;
- No major neurological or mental illness, no head injury, alcohol dependence or drug dependence;
- During the experiment, the subjects did not smoke, drink, get sick and take psychotropic drugs, and there were no major life events that caused mood changes.
Who Should NOT Join This Trial:
- organic brain injury, neurological diseases or serious physical diseases;
- Have a history of substance abuse and drug dependence, or have used antipsychotic drugs in the past three months, and have serious suicidal tendencies;
- There are contraindications for MRI or EEG or transcranial magnetic stimulation.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Clinical diagnosis of refractory epilepsy
* Right-handed and aged 18-50 years old and primary school education or above;
* No major neurological or mental illness, no head injury, alcohol dependence or drug dependence;
* During the experiment, the subjects did not smoke, drink, get sick and take psychotropic drugs, and there were no major life events that caused mood changes.
Exclusion Criteria:
* organic brain injury, neurological diseases or serious physical diseases;
* Have a history of substance abuse and drug dependence, or have used antipsychotic drugs in the past three months, and have serious suicidal tendencies;
* There are contraindications for MRI or EEG or transcranial magnetic stimulation.
Treatments Being Tested
DEVICE
Active Comparator: Unilateral real High definition transcranial direct current stimulation
Improvement of cortical excitability, unilateral stimulation was effective, and no side effects were observed
DEVICE
Active Comparator: Bilateral real High definition transcranial direct current stimulation
Improved cortical excitability, the effect was more obvious than unilateral stimulation, the effect lasted longer, and no side effects were observed
DEVICE
Sham Comparator: Sham High definition transcranial direct current stimulation
The sham stimulation is mainly used for blank control, control variables, and exclude the interference of other factors
Locations (1)
Anhui Medical University
Hefei, Anhui, China