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RECRUITINGOBSERVATIONAL

Neural and Cognitive Consequences of COVID-19 Survival

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). This translates to millions of people surviving COVID19 infection. While the lungs are ground zero, COVID tears through organ systems from brain to blood vessels. We are now beginning to see people recover but complain of ongoing problems, including lingering cognitive problems, depression, and anxiety. We have brought together 2 laboratories with complementary techniques including psychological testing and neuroimaging methods togethers with markers in the blood that may signal damage in the brain. A close look at these problems is timely and imperative if we are to understand the pathophysiology of 'COVID brain' and prepare for downstream problems.

Who May Be Eligible (Plain English)

Who May Qualify: - Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco. - Because this study includes an MRI, part of the screening process will be to ensure you don't have any metal in your body, you do not have head or neck tattoos, and you are comfortable inside the MRI scanner. - 18-70 years with a confirmed COVID infection at least 3 months ago. - Negative metal screen for MRI safety - Normal (or corrected to normal) vision Who Should NOT Join This Trial: - Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms) - Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms - Major medical conditions (e.g., seizures disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology) - Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions - Known claustrophobia - Current pregnancy - IQ estimate \< 70 Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco. * Because this study includes an MRI, part of the screening process will be to ensure you don't have any metal in your body, you do not have head or neck tattoos, and you are comfortable inside the MRI scanner. * 18-70 years with a confirmed COVID infection at least 3 months ago. * Negative metal screen for MRI safety * Normal (or corrected to normal) vision Exclusion Criteria: * Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms) * Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms * Major medical conditions (e.g., seizures disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology) * Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions * Known claustrophobia * Current pregnancy * IQ estimate \< 70

Treatments Being Tested

OTHER

cross-sectional MRI and EEG assessments (NO INTERVENTION)

n/a there is no intervention in this observational study

Locations (1)

San Francisco Heathcare System
San Francisco, California, United States