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RECRUITINGPhase 4INTERVENTIONAL

Clinical Comparison of Low-dose Rosuvastatin Plus Ezetimibe Combination Therapy and High-dose Rosuvastatin Monotherapy in Patients With Minimal to Intermediate Coronary Artery Disease Without Percutaneous Coronary Intervention

Clinical Comparison of Low-dose Rosuvastatin Plus Ezetimibe Combination Therapy and High-dose Rosuvastatin Monotherapy in Patients With Minimal to Intermediate Coronary Artery Disease Without Percutaneous Coronary Intervention : A Prospective, Multicenter, Randomized, Open-label Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

\[Purpose of the Clinical Study\]:The purpose of this study is to conduct a clinical comparison of low-dose rosuvastatin plus ezetimibe combination therapy and high-dose rosuvastatin monotherapy in patients with minimal to intermediate coronary artery disease without percutaneous coronary intervention to confirm non-inferiority in the reduction of key cardiovascular events. \[Hypothesis\]:In patients who have not undergone percutaneous coronary intervention for minimal to moderate coronary artery disease, low-dose rosuvastatin and ezetimibe combination therapy are non-inferior in terms of reducing major cardiovascular events compared to high-dose rosuvastatin monotherapy.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Male and female adjusts (19 or older) 2. Patients with suspected stable angina pectoris without coronary artery interventions, who showed a minimal to intermediate coronary artery diseases (a stenosis of 10 to 70% diameter as per QCA) in at least one natural coronary artery in coronary artery angiography or coronary artery CT. 3. Patients who gave their willing to sign a consent form themselves in writing. 4. Patients who were treated with statin or lipid-lowering agents may participate in the study by changing the existing medicines. Who Should NOT Join This Trial: 1. Patients with an intermediate (\>30%) lesion on the left main coronary artery. 2. Patients diagnosed with acute coronary artery diseases (STEMI, NSTEMI, Unstable angina) 3. Patients who received percutaneous coronary intervention 4. Patients who have been diagnosed with stroke, transitory ischemic attack, and peripheral artery diseases. 5. Patients diagnosed with variant myocardial infarction 6. Patients with severe liver diseases or lung diseases and/or malignant tumor with life expectancy of less than 3 years 7. Patients with severe valvular heart disease 8. Patients who are hypersensitive or prohibited from using the active substance (Ezetimibe or Rosuvastatin) of the study medicines 9. Patients with cardiogenic shock 10. Pregnant women or women who are planning to get pregnant 11. Patients who are receiving hemodialysis or peritoneal dialysis or received renal transplantation due to end-stage renal failure 12. Patients who participated in other clinical studies within the past three months (except for non-interventional observation studies) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Male and female adjusts (19 or older) 2. Patients with suspected stable angina pectoris without coronary artery interventions, who showed a minimal to intermediate coronary artery diseases (a stenosis of 10 to 70% diameter as per QCA) in at least one natural coronary artery in coronary artery angiography or coronary artery CT. 3. Patients who gave their informed consent themselves in writing. 4. Patients who were treated with statin or lipid-lowering agents may participate in the study by changing the existing medicines. Exclusion Criteria: 1. Patients with an intermediate (\>30%) lesion on the left main coronary artery. 2. Patients diagnosed with acute coronary artery diseases (STEMI, NSTEMI, Unstable angina) 3. Patients who received percutaneous coronary intervention 4. Patients who have been diagnosed with stroke, transitory ischemic attack, and peripheral artery diseases. 5. Patients diagnosed with variant myocardial infarction 6. Patients with severe liver diseases or lung diseases and/or malignant tumor with life expectancy of less than 3 years 7. Patients with severe valvular heart disease 8. Patients who are hypersensitive or prohibited from using the active substance (Ezetimibe or Rosuvastatin) of the study medicines 9. Patients with cardiogenic shock 10. Pregnant women or women who are planning to get pregnant 11. Patients who are receiving hemodialysis or peritoneal dialysis or received renal transplantation due to end-stage renal failure 12. Patients who participated in other clinical studies within the past three months (except for non-interventional observation studies)

Treatments Being Tested

DRUG

Combination drug group of Ezetimibe 10 mg/Rosuvastatin 5 mg

Oral administration once a day, taking it for 3 years

DRUG

Mono drug group of Rosuvastatin 20 mg

Oral administration once a day, taking it for 3 years

Locations (1)

St. Vincent's Hospital
Suwon, Gyeonggi-do, South Korea