RECRUITINGOBSERVATIONAL

Auditory Functions in Patients With Multiple Sclerosis

Electrophysiological Studies of Auditory Functions and CSF Analyses in Patients With Multiple Sclerosis

About This Trial

The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers. The results of DPOAE and CSF will be correlated to identify statistically significant correlation.

Who May Be Eligible (Plain English)

Inclusion Criteria - age \>18 and \<50, - no history of hearing loss, - no psychiatric condition - no familial history of otosclerosis/deafness/genetic hearing loss - patients with PD and/or MS. Exclusion Criteria - Conductive hearing loss - stroke \< 2 years - cardiovascular disease non under control - diabetes - hypotensive disorders - alcohol abuse - recreational drug consumption - epilepsy Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria * age \>18 and \<50, * no history of hearing loss, * no psychiatric condition * no familial history of otosclerosis/deafness/genetic hearing loss * patients with PD and/or MS. Exclusion Criteria * Conductive hearing loss * stroke \< 2 years * cardiovascular disease non under control * diabetes * hypotensive disorders * alcohol abuse * recreational drug consumption * epilepsy

Treatments Being Tested

DIAGNOSTIC_TEST

Auditory test

The patients will perform: Pure Tone Auditory test + Tympanometry and Stapedial Reflex * Speech Perception test * In case of tinnitus: tinnitus questionnaire and acuphenometry * DPOAEs * ABR

OTHER

CSF sampling

Cerebrospinal Fluid will be collected by lumbar puncture and analyzed

Locations (1)

Arianna Di Stadio

Catania, Sicily, Italy