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RECRUITINGOBSERVATIONAL

Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.

Who May Be Eligible (Plain English)

Who May Qualify: - Infants \<12 months - With bronchiolitis during RSV epidemic season - No chronic illness - No bronchiolitis medical history - Signed consent from parents or legal guardians Who Should NOT Join This Trial: - Chronic respiratory illness - Medical history of bronchiolitis or newborn asthma - Treatment with immunosuppressants - Patient with no social security affiliation Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Infants \<12 months * With bronchiolitis during RSV epidemic season * No chronic illness * No bronchiolitis medical history * Signed consent from parents or legal guardians Exclusion Criteria: * Chronic respiratory illness * Medical history of bronchiolitis or newborn asthma * Treatment with immunosuppressants * Patient with no social security affiliation

Treatments Being Tested

OTHER

Sampling

Single-time sampling of respiratory virus-infected children

Locations (3)

APHP, Antoine Béclère Hospital
Clamart, France
AP-HP,Raymond Poincaré Hospital
Garches, France
Réanimation médico-chirurgicale Necker
Paris, France