RECRUITINGINTERVENTIONAL

Nutrition for Asthmatics

Individualized Nutrition to Help Asthmatics Improve Lung Function and Energetics (INHALE)

About This Trial

Determine to what extent three distinct dietary approaches improve asthma control and lung function.

Who May Be Eligible (Plain English)

Who May Qualify: - Age: 18-65 years - BMI: 18.5 - 29.99 kg/m2 - asthma diagnosed by medical specialist (confirmed in medical history) - partly controlled or uncontrolled asthma by Asthma Control Test score ≤22 - owns a device compatible with ZEPHYRx platform - stable asthma medication use (no change in the past 2 months). Who Should NOT Join This Trial: - Diabetes or using diabetes medications that may lower blood glucose levels - point of care fasting blood glucose ≥126 mg/dl or triglycerides ≥400 mg/dl - current smoking or smoking history of greater than 10 pack-years - other significant respiratory or cardiac disease or the presence of clinically important comorbidities, e.g., COPD, renal failure, liver disease; uncontrolled hypertension defined as systolic blood pressure ≥160 mm/Hg, or diastolic blood pressure ≥100 mm/Hg - pregnant or nursing women - food preferences or allergies inconsistent with study diet capabilities - noncompliance with lead-in period requirements. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Age: 18-65 years * BMI: 18.5 - 29.99 kg/m2 * asthma diagnosed by medical specialist (confirmed in medical history) * partly controlled or uncontrolled asthma by Asthma Control Test score ≤22 * owns a device compatible with ZEPHYRx platform * stable asthma medication use (no change in the past 2 months). Exclusion Criteria: * Diabetes or using diabetes medications that may lower blood glucose levels * point of care fasting blood glucose ≥126 mg/dl or triglycerides ≥400 mg/dl * current smoking or smoking history of greater than 10 pack-years * other significant respiratory or cardiac disease or the presence of clinically important comorbidities, e.g., COPD, renal failure, liver disease; uncontrolled hypertension defined as systolic blood pressure ≥160 mm/Hg, or diastolic blood pressure ≥100 mm/Hg * pregnant or nursing women * food preferences or allergies inconsistent with study diet capabilities * noncompliance with lead-in period requirements.

Treatments Being Tested

OTHER

DGA Diet

A fully provisioned isocaloric, isonitrogenous study diet following the Dietary Guidelines for Americans (DGA) Including: * A variety of vegetables and fruits * Grains, at least half of which are whole grains * Fat-free or low-fat dairy * A variety of protein foods, including seafood, lean meats and poultry, eggs, legumes, nuts, and seeds * This healthy eating pattern also limits saturated fats and trans fats, added sugars, and sodium.

OTHER

MCT Diet

A fully provisioned isocaloric, isonitrogenous study diet following the Dietary Guidelines for Americans supplemented with medium chain triglycerides (MCT).

OTHER

KETO Diet

A fully provisioned isocaloric, isonitrogenous ketogenic study diet.

Locations (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States